TY  - JOUR
AB  - Type 1 diabetes (T1D) is one of the most common chronic diseases in childhood caused by autoimmune-mediated destruction of the insulin-producing pancreatic islet ß-cells. Prospective birth cohort studies contributed to the identification of genetic and environmental factors involved in the pathogenesis of type 1 diabetes. The development and validation of a genetic risk score enabled risk prediction for later development of type 1 diabetes. Consistent findings from prospective studies point to the contribution of intrauterine maternal type 1 diabetes exposure, early childhood viral infections, early childhood growth/obesity, and gut microbiome/dysbiosis in the pathogenesis of type 1 diabetes. Launched in late 2017, the Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) was designed to carry out newborn screening in the general population, identify infants at high genetic risk of developing type 1 diabetes, and offer them participation in trials to prevent disease initiation.
AU  - Hummel, S.
AU  - Ziegler, A.-G.
C1  - 69914
C2  - 55000
SP  - 86-96
TI  - Genetic predisposition and environmental factors in the pathogenesis of type 1 diabetes.
JO  - Padiat. Praxis
VL  - 100
IS  - 1
PY  - 2023
SN  - 0030-9346
ER  - 

TY  - JOUR
AB  - The human microbiome is represented by a variety of microorganisms including bacteria, archaea, viruses and fungi that live on and inside our body. Most of them do not cause disease. In fact, microbes provide many important functions that humans did not develop themselves. They can digest food and supply host cells with nutrients, metabolize drugs, and activate and support the host's immune system. Knowledge about the microbiome has expanded with the development of novel culture-independent techniques, which revealed that healthy lungs also harbor diverse microbial communities and that variations in their composition can correlate with severity of lung diseases. Limited experimental evidence suggests an influence of the gut microbiome on respiratory health, involving different communication pathways, such as through the release of gut microbial metabolites, or via induced host metabolites or gut-lung immune cell trade. This implies that nutrition, by shaping the gut microbiome, could have an impact on respiratory diseases. However, this requires a precise mechanistic understanding how the gut microbiome affects microbial communities in the lungs and vice versa. Once better understood, this mechanism could be of particular interest in the future for the application of nutritive strategies in critical time window during the early childhood to improve lung health.
AU  - Lund, J.V.*
AU  - Kovacevic, D.*
AU  - Schloter, M.
AU  - Krauss-Etschmann, S.*
C1  - 60184
C2  - 49296
SP  - 444-452
TI  - The role of the gut-lung axis in respiratory health.
JO  - Padiat. Praxis
VL  - 93
IS  - 3
PY  - 2020
SN  - 0030-9346
ER  - 

TY  - JOUR
AU  - Förster, K.
AU  - Frank, A.
AU  - Ehrhardt, H.*
AU  - Hilgendorff, A.
C1  - 60176
C2  - 49286
SP  - 604-611
TI  - Neue diagnostische Werkzeuge für die frühzeitige Identifikation und strukturelle Charakterisierung der Bronchopulmonalen Dysplasie.
JO  - Padiat. Praxis
VL  - 92
IS  - 4
PY  - 2019
SN  - 0030-9346
ER  -