TY  - JOUR
AB  - Background: Anesthesia, nerve 
      block, therapeutic injections, and biopsies all require an acupuncture 
      intervention. However, traditional two-dimensional (2D) 
      ultrasound-guided needle puncture is often challenging and therefore 
      requires the use of three-dimensional (3D) ultrasound images to 
      accurately identify and evaluate the patient’s anatomical structure.
                          Methods: In this study, a 3D 
      multi-modal intelligent intervention system using electromagnetic 
      navigation for real-time positioning and ultrasound images was 
      described. A total of 190 cases requiring puncture were randomly divided
       into control (conventional 2D ultrasound instrument) and experimental 
      (novel 3D ultrasound imedis9000) groups. The advantages and 
      disadvantages of the two puncture methods were prospectively analyzed in
       the 190 cases, and the feasibility of electromagnetic navigation 
      real-time positioning was compared to ultrasound imaging.
                          Results: This study included 190
       cases from two centers that required puncture treatment and were 
      randomly assigned to the control (conventional 2D ultrasound instrument;
       n=95) or the experimental (novel 3D ultrasound imedis9000; n=95) 
      groups. Percutaneous vascular puncture, percutaneous biopsy, 
      percutaneous bile duct puncture, thoracic paravertebral nerve block, and
       sciatic nerve block operations were performed separately. The results 
      indicated that the puncture time and number of trials in the 
      experimental group were significantly lower than those in the control 
      group. No significant difference was identified in the basic vital signs
       between the two groups before and after surgery. The success rate of 
      the novel 3D ultrasound imedis9000 was 100%, and the success rate of the
       conventional 2D ultrasound instrument was 95.7%. Furthermore, the 
      results also showed that the novel 3D ultrasound imedis9000 and the 
      matching coaxial positioning channel puncture needle had low pain, good 
      toughness and strength, and great convenience.
                          Conclusions: The new 3D 
      multi-modal intelligent intervention system using electromagnetic 
      navigation real-time positioning and ultrasound images has significant 
      advantages compared with conventional 2D ultrasound in terms of puncture
       time, number of trials, operation difficulty, and convenience, and is 
      worthy of further promotion and use in clinics.
                          Trial Registration: Beijing Municipal Drug Administration, 20190015.
AU  - Tang, W.*
AU  - Zhou, Y.*
AU  - Zhao, H.*
AU  - Sun, G.*
AU  - Rong, D.*
AU  - Li, Z.*
AU  - Hu, M.*
AU  - Han, L.F.*
AU  - He, X.*
AU  - Zhao, S.*
AU  - Chen, X.*
AU  - Yuan, H.*
AU  - Chen, S.*
AU  - Wang, Q.
AU  - Gu, J.*
AU  - Wang, X.*
AU  - Song, J.*
C1  - 65410
C2  - 52282
TI  - A 3D multi-modal intelligent intervention system using electromagnetic navigation for real-time positioning and ultrasound images: A prospective randomized controlled trial.
JO  - Ann. Transl. Med.
VL  - 10
IS  - 11
PY  - 2022
SN  - 2305-5839
ER  - 

TY  - JOUR
AB  - Background: Current imaging assessment of peripheral artery disease (PAD) relies on anatomical cross-sectional visualizations of the affected arteries. Multispectral optoacoustic tomography (MSOT) is a novel molecular imaging technique that provides direct and label-free visualizations of soft tissue perfusion and oxygenation. Methods: MSOT was prospectively assessed in a pilot trial in healthy volunteers (group n1=4, mean age 31, 50% male and group n3=4, mean age 37.3, 75% male) and patients with intermittent claudication (group n2=4, mean age 72, 75% male, PAD stage IIb). We conducted cuff-induced ischemia (group n1) and resting state measurements (groups n2 and n3) over the calf region. Spatially resolved mapping of oxygenated (HbO2), deoxygenated (Hb) and total (THb) hemoglobin, as well as oxygen saturation (SO2), were measured via hand-held hybrid MSOT-Ultrasound based purely on hemoglobin contrast. Results: Calf measurements in healthy volunteers revealed distinct dynamics for HbO2, Hb, THb and SO2 under cuff-induced ischemia. HbO2, THb and SO2 levels were significantly impaired in PAD patients compared to healthy volunteers (P<0.05 for all parameters). Revascularization led to significant improvements in HbO2 of the affected limb. Conclusions: Clinical MSOT allows for non-invasive, label-free and real-time imaging of muscle oxygenation in health and disease with implications for diagnostics and therapy assessment in PAD.
AU  - Karlas, A.
AU  - Masthoff, M.*
AU  - Kallmayer, M.*
AU  - Helfen, A.*
AU  - Bariotakis, M.
AU  - Fasoula, N.-A.
AU  - Schäfers, M.*
AU  - Seidensticker, M.*
AU  - Eckstein, H.H.*
AU  - Ntziachristos, V.
AU  - Wildgruber, M.*
C1  - 61331
C2  - 49788
CY  - Flat-rm C 16f, Kings Wing Plaza 1, No 3 Kwan St, Shatin, Hong Kong 00000, Peoples R China
TI  - Multispectral optoacoustic tomography of peripheral arterial disease based on muscle hemoglobin gradients-a pilot clinical study.
JO  - Ann. Transl. Med.
VL  - 9
IS  - 1
PB  - Ame Publ Co
PY  - 2021
SN  - 2305-5839
ER  -