TY  - JOUR
AU  - Gabriel, K.*
AU  - Kobold, S.
C1  - 75122
C2  - 57820
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Long-term consequences of cancer therapy: cognitive impairment following CAR T cell therapy.
JO  - Signal Transduct. Target. Ther.
VL  - 10
IS  - 1
PB  - Springernature
PY  - 2025
SN  - 2095-9907
ER  - 

TY  - JOUR
AB  - Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity. G protein-coupled receptors (GPCRs) are among the main modulators of metabolism and energy balance. They, for instance, regulate appetite and satiety in certain hypothalamic neurons, as well as glucose and lipid metabolism and hormone secretion from adipocytes. Mutations in some GPCRs, such as the melanocortin receptor type 4 (MC4R), have been associated with early-onset obesity. Here, we identified the adhesion GPCR latrophilin 1 (ADGRL1/LPHN1) as a member of the regulating network governing food intake and the maintenance of energy balance. Deficiency of the highly conserved receptor in mice results in increased food consumption and severe obesity, accompanied by dysregulation of glucose homeostasis. Consistently, we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from obesity. Therefore, we propose that LPHN1 dysfunction is a risk factor for obesity development.
AU  - Dietzsch, A.N.*
AU  - Al-Hasani, H.*
AU  - Altschmied, J.*
AU  - Bottermann, K.*
AU  - Brendler, J.*
AU  - Haendeler, J.*
AU  - Horn, S.*
AU  - Kaczmarek, I.*
AU  - Körner, A.
AU  - Krause, K.*
AU  - Landgraf, K.*
AU  - Le Duc, D.*
AU  - Lehmann, L.*
AU  - Lerch, S.*
AU  - Pick, S.*
AU  - Ricken, A.*
AU  - Schnorr, R.*
AU  - Schulz, A.*
AU  - Strnadová, M.*
AU  - Velluva, A.*
AU  - Zabri, H.*
AU  - Schöneberg, T.*
AU  - Thor, D.*
AU  - Prömel, S.*
C1  - 70559
C2  - 55686
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
JO  - Signal Transduct. Target. Ther.
VL  - 9
IS  - 1
PB  - Springernature
PY  - 2024
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Jiang, D.*
AU  - Machens, H.G.*
AU  - Rinkevich, Y.
C1  - 71282
C2  - 56012
TI  - Sensory neurons: Unveiling the symphony of wound healing.
JO  - Signal Transduct. Target. Ther.
VL  - 9
IS  - 1
PY  - 2024
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Masserdotti, G.
C1  - 71987
C2  - 56349
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Late onset Alzheimer's disease: Modeling disease hallmarks via in vitro 3D iNeuron cultures.
JO  - Signal Transduct. Target. Ther.
VL  - 9
IS  - 1
PB  - Springernature
PY  - 2024
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Yan, X.
AU  - Ussar, S.
C1  - 70860
C2  - 55784
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Cellular precision modulation of JAK1: Tailoring therapies for allergic lung inflammation.
JO  - Signal Transduct. Target. Ther.
VL  - 9
IS  - 1
PB  - Springernature
PY  - 2024
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Boes, M.*
AU  - Falter-Braun, P.
C1  - 68972
C2  - 53902
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Long-COVID-19: The persisting imprint of SARS-CoV-2 infections on the innate immune system.
JO  - Signal Transduct. Target. Ther.
VL  - 8
IS  - 1
PB  - Springernature
PY  - 2023
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Jeridi, A.
AU  - Kapellos, T.
AU  - Yildirim, A.Ö.
C1  - 68327
C2  - 54739
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Fumarate hydratase: A new checkpoint of metabolic regulation in inflammatory macrophages.
JO  - Signal Transduct. Target. Ther.
VL  - 8
IS  - 1
PB  - Springernature
PY  - 2023
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Gregor, L.*
AU  - Stock, S.*
AU  - Kobold, S.
C1  - 65725
C2  - 52467
TI  - ESCRT machinery: Role of membrane repair mechanisms in escaping cell death.
JO  - Signal Transduct. Target. Ther.
VL  - 7
IS  - 1
PY  - 2022
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Popowicz, G.M.
AU  - Pyrc, K.*
AU  - Hadian, K.
C1  - 64941
C2  - 51980
TI  - Vaccination versus SARS-CoV-2 Omicron: Three vaccine doses win the battle.
JO  - Signal Transduct. Target. Ther.
VL  - 7
IS  - 1
PY  - 2022
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Willemsen, N.*
AU  - Kotschi, S.*
AU  - Bartelt, A.
C1  - 66673
C2  - 53263
TI  - Fire up the pyre: Inosine thermogenic signaling for obesity therapy.
JO  - Signal Transduct. Target. Ther.
VL  - 7
IS  - 1
PY  - 2022
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Conlon, T.M.
AU  - Knolle, P.A.*
AU  - Yildirim, A.Ö.
C1  - 62739
C2  - 51032
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Local tissue development of type 1 innate lymphoid cells: Guided by interferon-gamma.
JO  - Signal Transduct. Target. Ther.
VL  - 6
IS  - 1
PB  - Springernature
PY  - 2021
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Jiang, D.
AU  - Rinkevich, Y.
C1  - 62966
C2  - 51210
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Converting fibroblastic fates leads to wound healing without scar.
JO  - Signal Transduct. Target. Ther.
VL  - 6
IS  - 1
PB  - Springernature
PY  - 2021
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Unterer, M.
AU  - Khan Mirzaei, M.
AU  - Deng, L.
C1  - 62102
C2  - 50650
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - Gut phage database: Phage mining in the cave of wonders.
JO  - Signal Transduct. Target. Ther.
VL  - 6
IS  - 1
PB  - Springernature
PY  - 2021
SN  - 2095-9907
ER  - 

TY  - JOUR
AU  - Conrad, M.
AU  - Novikova, M.*
C1  - 60487
C2  - 49846
CY  - Campus, 4 Crinan St, London, N1 9xw, England
TI  - A cozy niche in an iron world.
JO  - Signal Transduct. Target. Ther.
VL  - 5
IS  - 1
PB  - Springernature
PY  - 2020
SN  - 2095-9907
ER  -