TY  - JOUR
AB  - Nanostructured heterojunctions offer a promising solution to overcome the limitations of narrow absorption spectra, limited penetration depths, and potential harm to healthy cells in phototherapy for clear cell renal cell carcinoma (ccRCC) treatment with nanomaterials. In this study, a heterostructure (PCN@HP) by decorating Hittorf's phosphorus nanorods onto biocompatible polymeric carbon nitride (PCN), enabling excitation by NIR light is designed. Compared with PCN and HP alone, the synthesized heterostructure generated localized heat upon broad absorption spectra of irradiation, boosting charge migration and separation, generating cytotoxic reactive oxygen species (ROS). Then, via in vitro and in vivo experiments, it is confirmed that the NIR-mediated PCN@HP heterojunction is a safe and effective approach for synchronous photothermal and photodynamic therapy treatment of ccRCC. Collectively, the PCN@HP heterojunction holds great potential as a non-invasive synergistic, dual-mode therapeutic nanomedicine for efficient tumor nano-therapy.
AU  - Guan, C.*
AU  - Li, C.*
AU  - Yang, C.*
AU  - Yang, D.*
AU  - Zhang, L.*
AU  - Xu, L.*
AU  - Liu, K.*
AU  - Zhang, N.*
AU  - Li, T.*
AU  - Song, Z.*
AU  - Che, L.*
AU  - Wang, Y.*
AU  - Zhang, L.
AU  - Li, D.*
AU  - Zhu, Y.*
AU  - Xu, Y.*
C1  - 70284
C2  - 55484
CY  - Postfach 101161, 69451 Weinheim, Germany
TI  - Enhanced renal carcinomat treatment via synergistic photothermal/photodynamic therapy using hittorf's phosphorus-decorated polymeric carbon nitride heterostructure.
JO  - Adv. Opt. Mater.
VL  - 2024
PB  - Wiley-v C H Verlag Gmbh
PY  - 2024
SN  - 2195-1071
ER  - 

TY  - JOUR
AB  - The recent development of ultrasound sensing using the silicon-photonics platform has enabled super-resolution optoacoustic imaging not possible by piezoelectric technology or polymeric optical microresonators. The silicon waveguide etalon detector (SWED) design exploits the sub-micrometer light confinement in the cross-section of a silicon strip waveguide to achieve a sensor aperture which is 13-fold to 30-fold smaller than the cutoff wavelength of the sensor. While its performance in near-field scanning optoacoustic imaging has been previously studied, the operational characteristics of this sensor as it relates to conventional optoacoustic imaging applications are not known. Here, for the first time, the application of the SWED in optoacoustic mesoscopy is investigated, the interaction of the sensor with ultrasound in the far-field is characterized, the acoustic point spread function up to a depth of 10 mm is measured, and 3D vasculature-mimicking phantoms are imaged. The measured point spread function of the sensor shows that surface acoustic waves can degrade the lateral resolution. Nevertheless, superior resolution is demonstrated over any state-of-the-art ultrasound sensor, over the whole range of imaging depths that are of interest to optoacoustic mesoscopy. Silicon photonics is proposed as a powerful and promising new platform for ultrasonics and optoacoustics.
AU  - Shnaiderman, R.
AU  - Mustafa, Q.
AU  - Ülgen, O.
AU  - Wissmeyer, G.
AU  - Estrada, H.
AU  - Razansky, D.
AU  - Chmyrov, A.
AU  - Ntziachristos, V.
C1  - 62617
C2  - 50914
CY  - Postfach 101161, 69451 Weinheim, Germany
TI  - Silicon-photonics point sensor for high-resolution optoacoustic imaging.
JO  - Adv. Opt. Mater.
VL  - 9
IS  - 20
PB  - Wiley-v C H Verlag Gmbh
PY  - 2021
SN  - 2195-1071
ER  -