TY  - JOUR
AB  - BACKGROUND: Some studies have revealed various sleep patterns in adolescents and adults using multidimensional objective sleep parameters. However, it remains unknown whether these patterns are consistent from adolescence to young adulthood and how they relate to long-term obesity. METHODS: Seven-day accelerometry was conducted in German Infant Study on the influence of Nutrition Intervention PLUS environmental and genetic influences on allergy development (GINIplus) and Influence of Lifestyle factors on the development of the Immune System and Allergies in East and West Germany (LISA) birth cohorts during the 15-year and 20-year follow-ups, respectively. Five sleep clusters were identified by k-means cluster analysis using 12 sleep characteristics at each follow-up. Adjusted linear and logistic regression models using generalized estimating equations were examined. Further, the interaction effects with time of follow-ups and polygenic risk scores (PRS) for body mass index (BMI) were tested. RESULTS: Five sleep clusters were classified consistently in both adolescence (n = 1347, aged 14.3-16.4 years) and young adulthood (n = 1262, aged 19.5-22.4 years). Adolescents in the "good sleep", "delayed sleep phase", and "fragmented sleep" clusters displayed greater stability transitioning into young adulthood, while those in the "sleep irregularity and variability", and "prolonged sleep latency" clusters showed lower stability (n = 636). Compared to the "good sleep" cluster, the "prolonged sleep latency" cluster exhibited associations with higher BMI [β = 0.56, 95% confidence interval (CI) = (0.06, 1.05)] and increased odds of overweight/obesity [Odds ratio = 1.55, 95% CI = (1.02, 2.34)]. No significant PRS-sleep cluster interaction was found for BMI or overweight/obesity. Among males only, the "delayed sleep phase", "sleep irregularity and variability" and "fragmented sleep" clusters showed stronger associations with overweight/obesity as age increased. CONCLUSION: Adolescents and young adults shared five consistent sleep patterns, with the "prolonged sleep latency" pattern linked to higher BMI and overweight/obesity.
AU  - Wang, M.
AU  - Flexeder, C.
AU  - Harris, C.
AU  - Kress, S.*
AU  - Schikowski, T.*
AU  - Peters, A.
AU  - Standl, M.
C1  - 72942
C2  - 56858
CY  - Xixi Campus, Zhejiang University, No. 148 Tianmushan Road, Hangzhou, Zhejiang, Peoples R China
SP  - 48-61
TI  - Accelerometry-assessed sleep clusters and obesity in adolescents and young adults: A longitudinal analysis in GINIplus/LISA birth cohorts.
JO  - World J. Pediatr.
VL  - 21
IS  - 1
PB  - Zhejiang Univ Press
PY  - 2025
SN  - 1708-8569
ER  - 

TY  - JOUR
AB  - OBJECTIVES: To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1 (ISM1) and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with obesity. METHODS: The study population is a sub-cohort of the PUBMEP research project, consisting of a cross-sectional population of 119 pubertal children with overweight (17 boys, 19 girls), obesity (20 boys, 25 girls), and normal weight (17 boys, 21 girls). All subjects were classified into experimental groups according to their sex, obesity, and insulin resistance (IR) status. They were counted anthropometry, glucose and lipid metabolism, inflammation and cardiovascular biomarkers as well as isthmin-1 (ISM1) serum levels. This population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in children. Furthermore, the study population had blood whole-genome DNA methylation examined, allowing deepening into the obesity-ISM1 molecular relationship. RESULTS: Higher serum ISM1 levels were observed in boys with obesity than in normal weight (P = 0.004) and overweight (P = 0.007) boys. ISM1 serum levels were positively associated with body mass index (BMI) Z-score (P = 0.005) and fat mass (P = 0.058) and negatively associated with myeloperoxidase (MPO) (P = 0.043) in boys. Although we did not find associations between ISM1 serum levels and metabolic outcomes in girls, which may indicate a putative sexual dimorphism, fat mass was positively associated in all children, including boys and girls (P = 0.011). DNA methylation levels in two-enhancer-related CpG sites of ISM1 (cg03304641 and cg14269097) were associated with serum levels of ISM1 in children. CONCLUSIONS: ISM1 is associated with obesity in boys at the pubertal stage, elucidating how this protein might be of special relevance as a new biomarker of obesity in children. Further studies including a longitudinal design during puberty are needed.
AU  - Ruiz Ojeda, F.J.
AU  - Anguita-Ruiz, A.*
AU  - Rico, M.C.*
AU  - Leis, R.*
AU  - Bueno, G.*
AU  - Moreno, L.A.*
AU  - Gil-Campos, M.*
AU  - Gil, Á.*
AU  - Aguilera, C.M.*
C1  - 67116
C2  - 53557
CY  - Xixi Campus, Zhejiang University, No. 148 Tianmushan Road, Hangzhou, Zhejiang, Peoples R China
SP  - 864-872
TI  - Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys.
JO  - World J. Pediatr.
VL  - 19
IS  - 9
PB  - Zhejiang Univ Press
PY  - 2023
SN  - 1708-8569
ER  -