TY  - JOUR
AB  - Background and Objective: The Mediterranean-dietary approach to stop hypertension (DASH) Intervention for Neurodegenerative Delay (MIND) is n healthy dietary plan which showed protective effects on cognitive decline, cognitive performance, and dementia risk. Selenium is an element with nutritional and toxicological properties, whose role in neurological diseases is greatly debated. We aimed to perform individual-level selenium speciation analyses to understand the association of different selenium compounds (organic and inorganic) with MIND diet adherence. Methods: We recruited healthy and non-smoking blood donors from Northern Italy referred to the Transfusion Medicine Unit of Reggio Emilia Hospital in 20172019 period. We assessed adherence to MIND diet using the semi-quantitative EPIC-food frequency questionnaire, and total selenium and its species in serum. We used cubic spline regression analysis to investigate the association between selenium compounds and adherence to the MIND diet. Results: Out of 148 subjects, we performed serum speciation analyses 104 (males/females: 50/54), with median age 48.5 years. Median score of adherence to the MIND diet was 7.5 (interquartile range (IQR) 6.5-8.5), while median levels of total selenium were 116.5 µg/L (IQR 106.0-128.0 µg/L). Overall, we found that total selenium was negatively and linearly correlated with adherence to MIND diet, as in the case of organic selenium and the organic form selenoprotein P. Glutathione peroxidase-bound selenium and selenocysteine were U-shaped associated with MIND, with positive associations above 8-score. For inorganic selenium and specifically the selenate compound, an inverted U-shaped relation emerged with MIND diet, with negative relation above median level of adherence. Conclusions: Our results support the hypothesis that higher adherence to MIND corresponds to lower levels of selenium in serum, specifically selenoprotein P and selenate. Hence, these two compounds may have adverse effects on cognitive decline and dementia risk as suggested in recent studies.
AU  - Filippini, T.*
AU  - Urbano, T.*
AU  - Malavolti, M.*
AU  - Grioni, S.*
AU  - Agnoli, C.*
AU  - Sieri, S.*
AU  - Michalke, B.
C1  - 70317
C2  - 55510
SP  - 444-444
TI  - Serum selenium concentrations and adherence to the MIND diet in a Northern Italian population: A cross sectional study.
JO  - Popul. Med.
VL  - 5
PY  - 2023
SN  - 2654-1459
ER  - 

TY  - CONF
AB  - Background and Objective: The relation between selenium and cellular redox status is a greatly debated topic in human health. 8-oxo-7, 8-dihydro-2’deoxyguanosine (8-oxodG) is an oxidized derivative of deoxyguanosine and a sensitive biomarker of oxidative stress and genotoxicity. The present study assessed the extent to which selenium status was associated with urinary 8-oxodG concentrations in a Northern Italian population. Methods: Of 148 eligible subjects, 137 healthy and non-smoking blood donors living in the Reggio Emilia province during 2017–2019 were enrolled. We measured urinary 8-oxodG concentrations and used restricted cubic spline regression analyses to investigate the association between selenium status (estimated using food frequency questionnaires, urinary concentrations, and serum concentrations of selenium and selenium species) and 8-oxodG/g creatinine. Results:Median age of our population was 48.2 years. Median urinary selenium and 8-oxodG levels (n=137) were 22.02 µg/L and 3.21 µg/g creatinine, respectively. Median total serum (n=104) concentrations were 116.50 µg/L, while median dietary intake (n=137) was 78.7 µg/day. Little association between dietary, serum, or urinary selenium with 8-oxodG concentrations emerged in the overall population. Urinary selenium positively correlated with 8-oxodG levels in men, while in women an inverted U-shaped association emerged. Total organic selenium and selenoprotein P levels were positively associated with 8-oxodG until 100 µg/L and then the association became slightly inverse in both sexes. In males, glutathione peroxidase-bound selenium and selenomethionine were positively correlated with 8-oxodG, while negative associations emerged for inorganic species. In females, positive but weak associations emerged for organic selenium species. Conclusions: Results of our study suggest that even though total selenium exposure seems not associated with 8-oxodG, selected selenium species may largely differ in their association with this oxidative stress biomarker, and that effects modification by sex was encountered. Selenomethionine-bound selenium was the organic compound most strongly associated with 8-oxodG.
AU  - Urbano, T.*
AU  - Filippini, T.*
AU  - Malavolti, M.*
AU  - Michalke, B.
AU  - Fustinoni, S.*
AU  - Vinceti, M.*
C1  - 70271
C2  - 56048
TI  - Selenium exposure and oxidative stress and genotoxicity risk in a healthy Italian population: a cross sectional study.
JO  - Popul. Med.
VL  - 5
PY  - 2023
SN  - 2654-1459
ER  -