TY  - JOUR
AB  - In 2020, it was estimated that there were 155 million survivors of TB alive, all at risk of possible post TB disability. The 2nd International Post-Tuberculosis Symposium (Stellenbosch, South Africa) was held to increase global awareness and empower TB-affected communities to play an active role in driving the agenda. We aimed to update knowledge on post-TB life and illness, identify research priorities, build research collaborations and highlight the need to embed lung health outcomes in clinical TB trials and programmatic TB care services. The symposium was a multidisciplinary meeting that included clinicians, researchers, TB survivors, funders and policy makers. Ten academic working groups set their own goals and covered the following thematic areas: 1) patient engagement and perspectives; 2) epidemiology and modelling; 3) pathogenesis of post-TB sequelae; 4) post-TB lung disease; 5) cardiovascular and pulmonary vascular complications; 6) neuromuscular & skeletal complications; 7) paediatric complications; 8) economic-social and psychological (ESP) consequences; 9) prevention, treatment and management; 10) advocacy, policy and stakeholder engagement. The working groups provided important updates for their respective fields, highlighted research priorities, and made progress towards the standardisation and alignment of post-TB outcomes and definitions.
AU  - Allwood, B.W.*
AU  - Nightingale, R.*
AU  - Agbota, G.*
AU  - Auld, S.*
AU  - Bisson, G.P.*
AU  - Byrne, A.*
AU  - Dunn, R.M.*
AU  - Evans, D.*
AU  - Hoddinott, G.*
AU  - Günther, G.*
AU  - Islam, Z.*
AU  - Johnston, J.C.*
AU  - Kalyatanda, G.*
AU  - Khosa, C.*
AU  - Marais, S.*
AU  - Makanda, G.*
AU  - Mashedi, O.M.*
AU  - Meghji, J.*
AU  - Mitnick, C.*
AU  - Mulder, C.*
AU  - Nkereuwem, E.*
AU  - Nkereuwem, O.*
AU  - Ozoh, O.B.*
AU  - Rachow, A.
AU  - Romanowski, K.*
AU  - Seddon, J.A.*
AU  - Schoeman, I.*
AU  - Thienemann, F.*
AU  - Walker, N.F.*
AU  - Wademan, D.T.*
AU  - Wallis, R.*
AU  - van der Zalm, M.M.*
C1  - 71055
C2  - 55899
SP  - 111-123
TI  - Perspectives from the 2nd International Post-Tuberculosis Symposium: Mobilising advocacy and research for improved outcomes.
JO  - IJTLD Open
VL  - 1
IS  - 3
PY  - 2024
SN  - 3005-7590
ER  - 

TY  - JOUR
AB  - BACKGROUND: The increasing relevance of lung function testing in diagnosing and treating pulmonary diseases globally requires adequate spirometric reference equations. However, locally derived reference standards from African countries are widely missing. METHODS: This cross-sectional study was conducted in Southwestern Tanzania. Participants underwent a socio-demographic interview, anthropometric measurements and standardised spirometric lung function testing. Regression modelling was used to generate Tanzanian prediction equations for spirometry parameters forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1) and the FEV1/FVC ratio. RESULTS: Out of 400 recruited participants, 343 had usable spirometry results with respect to the American Thoracic Society (ATS)/European Respiratory Society (ERS) reproducibility and acceptability criteria. The mean age of participants was 32.65 years (SD 12.11), and 44,9% were females. Spirometric parameters increased with height but decreased with older age. The coefficients of our new prediction equations for spirometry parameters differed substantially from those of existing reference standards. CONCLUSION: This study provides prediction equations for spirometric lung function in a non-smoking Tanzanian population. The differences in existing equations underline the heterogeneity of locally derived reference equations in Africa and contribute insights and data to discussing global respiratory health care reference standards.
AU  - Wenzel, R.*
AU  - Siyame, E.*
AU  - Ivanova, O.*
AU  - Bakuli, A.*
AU  - Lalashowi, J.*
AU  - Zekoll, F.C.*
AU  - Hoelscher, M.
AU  - Sabi, I.*
AU  - Rachow, A.
AU  - Ntinginya, N.E.*
C1  - 72004
C2  - 56544
SP  - 473-479
TI  - Spirometric reference equations and lung function testing in adults from Southwestern Tanzania.
JO  - IJTLD Open
VL  - 1
IS  - 10
PY  - 2024
SN  - 3005-7590
ER  -