TY  - JOUR
AB  - Genome-wide association studies (GWAS) of common and low-frequency variants have discovered 164 genetic risk loci for restless legs syndrome (RLS) in adult populations of European ancestry. Sex-specific GWAS meta-analyses revealed largely overlapping genetic risk profiles for women and men and are in line with a nongenetic risk factor driving the higher prevalence seen in women. Genetic investigations of pediatric RLS are limited, but the likely inclusion of early-onset cases in GWAS of adult populations and the similar phenotypic presentation of both forms suggest that genetic risk variants identified in adult populations transfer to pediatric RLS.
AU  - Schormair, B.
C1  - 74491
C2  - 57491
CY  - 525 B Street, Ste 1900, San Diego, Ca 92101-4495 Usa
SP  - 193-202
TI  - Genetics of restless legs syndrome: Insights from genome-wide association studies.
JO  - Sleep Med. Clin.
VL  - 20
IS  - 2
PB  - Elsevier Inc
PY  - 2025
SN  - 1556-407X
ER  -