TY  - JOUR
AB  - We previously described an increased incidence of HIV among individuals infected with Wuchereria bancrofti
       (WB). However, no host, parasite, or viral factors were reported as 
      directly associated with the increase in HIV incidence in this group. To
       investigate this, we compared T cell phenotypes between WB+ and WB− 
      women. Flow cytometry analysis of activation and differentiation markers
       on CD4 T cells, as well as HIV entry receptor CCR5 was performed on 
      cervical and peripheral blood samples from 54 women living without HIV 
      (WLWoH). Additionally, HPV testing was performed on their specimens and 
      for 13 WLWH. WB infection was associated with a significantly increased 
      frequency of CD3+γδ2+ T cells in the cervical mucosa (median 4.0% vs. 1.4%, p
       = 0.012). Contrary to our expectations, we found lower frequencies of 
      CCR5 on total, memory and activated memory CD4 T cells in the WB+ group.
       However, differences diminished after accounting for age and site of 
      recruitment. WB and HIV infections were associated with an increased 
      likelihood of high-risk human papillomavirus (HR HPV) positivity. (WB 
      status: odds ratio (OR) 4.1, p = 0.066; HIV status: OR 5.5, p
       = 0.068). Our findings suggest immunological mechanisms by which WB 
      increases the risk for other infections, e.g., HIV and HR HPV, albeit 
      independent of the CCR5 receptor.
AU  - Mosoba, M.*
AU  - Marandu, T.F.*
AU  - Maganga, L.*
AU  - Mhidze, J.*
AU  - Mahenge, A.*
AU  - Mnkai, J.*
AU  - Urio, A.*
AU  - Chiwarengo, N.*
AU  - Torres, L.*
AU  - John, W.*
AU  - Ngenya, A.*
AU  - Kalinga, A.*
AU  - J mwingira, U.*
AU  - Ritter, M.*
AU  - Hoerauf, A.*
AU  - Horn, S.*
AU  - Geldmacher, C.*
AU  - Hoelscher, M.
AU  - Chachage, M.*
AU  - Kroidl, I.*
C1  - 76006
C2  - 58341
CY  - Mdpi Ag, Grosspeteranlage 5, Ch-4052 Basel, Switzerland
TI  - Impact of Wuchereria bancrofti Infection on cervical mucosal immunity and human papillomavirus prevalence in women from Lindi and Mbeya regions, Tanzania.
JO  - Trop. Med. Infect. Dis.
VL  - 10
IS  - 11
PB  - Mdpi
PY  - 2025
SN  - 2414-6366
ER  -