TY  - JOUR
AB  - An unprecedented heatwave swept the globe in 2023, marking it one of the hottest years on record and raising concerns about its health impacts. However, a comprehensive assessment of the heatwave-related mortality and its attribution to human-induced climate change remains lacking. We aim to address this gap by analyzing high-resolution climate and mortality data from 2,013 locations across 67 countries/territories using a three-stage modeling approach. First, we estimated historical heatwave-mortality associations using a quasi-Poisson regression model with distributed lag structures, considering lag effects, seasonality, and within-week variations. Second, we pooled the estimates in meta-regression, accounting for spatial heterogeneity and potential changes in heatwave-mortality associations over time. Third, we predicted grid-specific (0.5° × 0.5°) association in 2023 and calculated the heatwave-related excess deaths, death ratio, and death rate per million people. Attribution analysis was conducted by comparing heatwave-related mortality under factual and counterfactual climate scenarios. We estimated 178,486 excess deaths (95% empirical confidence interval [eCI], 159,892−204,147) related to the 2023 heatwave, accounting for 0.73% of global deaths, corresponding to 23 deaths per million people. The highest mortality rates occurred in Southern (120, 95% eCI, 116−126), Eastern (107, 95% eCI, 100−114), and Western Europe (66, 95% eCI, 62−70), where the excess death ratio was also higher. Notably, 54.29% (95% eCI, 45.71%−61.36%) of the global heatwave-related deaths were attributable to human-induced climate change. These results underscore the urgent need for adaptive public health interventions and climate mitigation strategies to reduce future mortality burdens in the context of increasing global warming.
AU  - Hundessa, S.*
AU  - Huang, W.*
AU  - Xu, R.*
AU  - Yang, Z.*
AU  - Zhao, Q.*
AU  - Gasparrini, A.*
AU  - Armstrong, B.*
AU  - Bell, M.L.*
AU  - Huber, V.
AU  - Urban, A.*
AU  - Coelho, M.R.*
AU  - Sera, F.*
AU  - Tong, S.*
AU  - Royé, D.*
AU  - Kyselý, J.*
AU  - de'Donato, F.*
AU  - Mistry, M.*
AU  - Tobias, A.*
AU  - Iñiguez, C.*
AU  - Ragettli, M.S.*
AU  - Hales, S.*
AU  - Achilleos, S.*
AU  - Klompmaker, J.*
AU  - Li, S.*
AU  - Guo, Y.*
C1  - 75759
C2  - 58121
TI  - Global excess deaths associated with heatwaves in 2023 and the contribution of human-induced climate change.
JO  - Innovation
VL  - 6
IS  - 10
PY  - 2025
SN  - 2666-6758
ER  - 

TY  - JOUR
AB  - Hyperglycemia is a key risk factor for death and disability worldwide. To better inform prevention strategies, we aimed to delineate and predict the temporal, spatial, and demographic patterns in mean fasting plasma glucose (FPG) levels and their related disease burden globally. Based on the Global Burden of Disease Study 2019, we estimated the distributions of mean FPG levels and high FPG-related disease burden by age, sex, year, socioeconomic status (SES), and geographical region from 1990 to 2050. We also investigated the possible associations of demographic, behavioral, dietary, metabolic, and environmental factors with FPG levels and high FPG-related disease burden. In 2019, the global mean FPG level was 5.40 mmol/L (95% uncertainty interval [UI]: 4.86-6.00), and high FPG contributed to 83.0 deaths (95% UI, 64.5-107.1) and 2,104.3 DALYs (95% UI: 1,740.7-2,520.7) per 100,000 people. For both historical (1990-2019) and future (2020-2050) periods, the mean FPG levels and the high FPG-related disease burden increased globally, with greater increases among the middle-aged and elderly, and people in low-to-middle SES countries, relative to their counterparts. Aging, unhealthy lifestyles, elevated body mass index, and lower air temperatures were potential risk factors for high FPG levels and the high FPG-related disease burden. This study demonstrates that high FPG continues to contribute to the global disease burden and is expected to do so for at least the next 30 years. Older people and those living in low-to-middle SES countries should receive more attention in glycemic management health interventions. In addition, effective interventions that target identified risk factors should be adopted to handle the increasingly large disease burden of high FPG.
AU  - Qiu, H.L.*
AU  - Fan, S.*
AU  - Zhou, K.*
AU  - He, Z.*
AU  - Browning, M.H.E.M.*
AU  - Knibbs, L.D.*
AU  - Zhao, T.
AU  - Luo, Y.N.*
AU  - Liu, X.X.*
AU  - Hu, L.X.*
AU  - Li, J.X.*
AU  - Zhang, Y.D.*
AU  - Xie, Y.T.*
AU  - Heinrich, J.
AU  - Dong, G.H.*
AU  - Yang, B.Y.*
C1  - 68073
C2  - 54551
CY  - 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
TI  - Global burden and drivers of hyperglycemia: Estimates and predictions from 1990 to 2050.
JO  - Innovation
VL  - 4
IS  - 4
PB  - Cell Press
PY  - 2023
SN  - 2666-6758
ER  - 

TY  - JOUR
AB  - The growing complexity of real-world systems necessitates interdisciplinary solutions to confront myriad challenges in modeling, analysis, management, and control. To meet these demands, the parallel systems method rooted in the artificial systems, computational experiments, and parallel execution (ACP) approach has been developed. The method cultivates a cycle termed parallel intelligence, which iteratively creates data, acquires knowledge, and refines the actual system. Over the past two decades, the parallel systems method has continuously woven advanced knowledge and technologies from various disciplines, offering versatile interdisciplinary solutions for complex systems across diverse fields. This review explores the origins and fundamental concepts of the parallel systems method, showcasing its accomplishments as a diverse array of parallel technologies and applications while also prognosticating potential challenges. We posit that this method will considerably augment sustainable development while enhancing interdisciplinary communication and cooperation.
AU  - Zhao, Y.*
AU  - Zhu, Z.*
AU  - Chen, B.*
AU  - Qiu, S.*
AU  - Huang, J.*
AU  - Lu, X.*
AU  - Yang, W.*
AU  - Ai, C.*
AU  - Huang, K.*
AU  - He, C.
AU  - Jin, Y.*
AU  - Liu, Z.*
AU  - Wang, F.Y.*
C1  - 68734
C2  - 54943
CY  - 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
TI  - Toward parallel intelligence: An interdisciplinary solution for complex systems.
JO  - Innovation
VL  - 4
IS  - 6
PB  - Cell Press
PY  - 2023
SN  - 2666-6758
ER  - 

TY  - JOUR
AB  - Studies have investigated the effects of heat and temperature variability (TV) on mortality. However, few assessed whether TV modifies the heat-mortality association. Data on daily temperature and mortality in the warm season were collected from 717 locations across 36 countries. TV was calculated as the standard deviation of the average of the same and previous days’ minimum and maximum temperatures. We used location-specific quasi-Poisson regression models with an interaction term between the cross-basis term for mean temperature and quartiles of TV to obtain heat-mortality associations under each quartile of TV, and then pooled estimates at the country, regional, and global levels. Results show the increased risk in heat-related mortality with increments in TV, accounting for 0.70% (95% confidence interval [CI]: −0.33 to 1.69), 1.34% (95% CI: −0.14 to 2.73), 1.99% (95% CI: 0.29–3.57), and 2.73% (95% CI: 0.76–4.50) of total deaths for Q1–Q4 (first quartile–fourth quartile) of TV. The modification effects of TV varied geographically. Central Europe had the highest attributable fractions (AFs), corresponding to 7.68% (95% CI: 5.25–9.89) of total deaths for Q4 of TV, while the lowest AFs were observed in North America, with the values for Q4 of 1.74% (95% CI: −0.09 to 3.39). TV had a significant modification effect on the heat-mortality association, causing a higher heat-related mortality burden with increments of TV. Implementing targeted strategies against heat exposure and fluctuant temperatures simultaneously would benefit public health.
AU  - Wu, Y.*
AU  - Wen, B.*
AU  - Li, S.*
AU  - Gasparrini, A.*
AU  - Tong, S.*
AU  - Overcenco, A.*
AU  - Urban, A.*
AU  - Schneider, A.E.
AU  - Entezari, A.*
AU  - Vicedo-Cabrera, A.M.*
AU  - Zanobetti, A.*
AU  - Analitis, A.*
AU  - Zeka, A.*
AU  - Tobias, A.*
AU  - Alahmad, B.*
AU  - Armstrong, B.*
AU  - Forsberg, B.*
AU  - Iñiguez, C.*
AU  - Ameling, C.*
AU  - De la Cruz Valencia, C.*
AU  - Åström, C.*
AU  - Houthuijs, D.*
AU  - Van Dung, D.*
AU  - Royé, D.*
AU  - Indermitte, E.*
AU  - Lavigne, E.*
AU  - Mayvaneh, F.*
AU  - Acquaotta, F.*
AU  - de'Donato, F.*
AU  - Sera, F.*
AU  - Carrasco-Escobar, G.*
AU  - Kan, H.*
AU  - Orru, H.*
AU  - Kim, H.*
AU  - Holobaca, I.H.*
AU  - Kyselý, J.*
AU  - Madureira, J.*
AU  - Schwartz, J.*
AU  - Katsouyanni, K.*
AU  - Hurtado-Diaz, M.*
AU  - Ragettli, M.S.*
AU  - Hashizume, M.*
AU  - Pascal, M.*
AU  - de Sousa Zanotti Stagliorio Coélho, M.*
AU  - Scovronick, N.*
AU  - Michelozzi, P.*
AU  - Goodman, P.J.*
AU  - Nascimento Saldiva, P.H.*
AU  - Abrutzky, R.*
AU  - Osorio, S.*
AU  - Dang, T.N.*
AU  - Colistro, V.*
AU  - Huber, V.*
AU  - Lee, W.*
AU  - Seposo, X.*
AU  - Honda, Y.*
AU  - Bell, M.L.*
AU  - Guo, Y.*
C1  - 64677
C2  - 51997
TI  - Fluctuating temperature modifies heat-mortality association around the globe.
JO  - Innovation
VL  - 3
IS  - 2
PY  - 2022
SN  - 2666-6758
ER  - 

TY  - JOUR
AB  - Multiple systematic reviews on greenspace and health outcomes exist, but the overall evidence base remains unclear. Therefore, we performed an umbrella review to collect and appraise all relevant systematic reviews of epidemiological studies on greenness exposure and health. We searched PubMed, Embase, and Web of Science from inception to June 28, 2021, and screened references of relevant articles. Systematic reviews with or without meta-analyses of epidemiological studies that examined the associations of greenness with any health outcome were included. Two independent investigators performed study selection and data extraction. We also evaluated the methodological quality of the included systematic reviews using the "Assessing the Methodological Quality of Systematic Reviews 2" checklist. A total of 40 systematic reviews and meta-analyses were included, of which most were cross-sectional studies conducted in high-income countries. Greenspace exposure was estimated with various objective and subjective parameters. Beneficial associations of greenspace with all-cause and stroke-specific mortality, CVD morbidity, cardiometabolic factors, mental health, low birth weight, physical activity, sleep quality, and urban crime were observed. No consistent associations between greenspace and other health outcomes (e.g., cancers) were observed. Most of the included systematic reviews and meta-analyses had one or more limitations in methodology. Our findings provide supportive evidence regarding the beneficial effects of greenspace exposure on some aspects of human health. However, the credibility of such evidence was compromised by methodological limitations. Better performed systematic reviews and meta-analyses as well as longitudinal designed primary studies are needed to validate this conclusion.
AU  - Yang, B.Y.*
AU  - Zhao, T.
AU  - Hu, L.X.*
AU  - Browning, M.H.E.M.*
AU  - Heinrich, J.
AU  - Dharmage, S.C.*
AU  - Jalaludin, B.*
AU  - Knibbs, L.D.*
AU  - Liu, X.X.*
AU  - Luo, Y.N.*
AU  - James, P.*
AU  - Li, S.*
AU  - Huang, W.Z.*
AU  - Chen, G.*
AU  - Zeng, X.W.*
AU  - Hu, L.W.*
AU  - Yu, Y.*
AU  - Dong, G.H.*
C1  - 63294
C2  - 51264
TI  - Greenspace and human health: An umbrella review.
JO  - Innovation
VL  - 2
IS  - 4
PY  - 2021
SN  - 2666-6758
ER  - 

TY  - JOUR
AU  - Kreyling, W.G.
AU  - Wohland, T.
C1  - 5714
C2  - 24377
SP  - 52-53
TI  - Bioimaging defence functions of the respiratory tract.
JO  - Innovation
VL  - 7
PB  - Carl Zeiss, Oberkochen
PY  - 2007
SN  - 2666-6758
ER  -