**********************************************************************************
*                                                                                                      
* GENERATING SERIES approach for Structural Identifiability Analysis   
*                                                                                                      
* Oana Chis, Julio R. Banga and Eva Balsa-Canto                                
*  BioProcess Engineering Group, IIM-CSIC, Vigo-Spain                        
*  contact: [chisoana,julio,ebalsa]@iim.csic.es                                     
*                                                                                                        
**********************************************************************************

Matlab version=9.1.0.441655 (R2016b)
Computer=PCWIN64
options:
                verbose: 1
                 noRank: 0
    problem_folder_path: 'D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\Results\NGF_Erk\run2'

STRUCTURAL IDENTIFIABILITY ANALYSIS FOR: NGF_Erk Model
 

***************
* INPUT DATA 
***************

-----> Maximum number of derivatives for the analysis: 15
-----> Dynamic model:
	A1=NGF_0*k_1*(k_3__TrkA_0 - k_3__TrkA_NGF) - k_2*k_3__TrkA_NGF
 
	A2=(k_4 + (k_3__TrkA_NGF*s_K^n)/(s_K^n + s__pErk^n))*(k_6__Ras_0 - k_6__RasGTP) - k_5*k_6__RasGTP
 
	A3=- k_7*k_8__pRaf - k_6__RasGTP*(k_8__pRaf - k_8__Raf_0)
 
	A4=- k_9*k_10__pMek - k_8__pRaf*(k_10__pMek - k_10__Mek_0)
 
	A5=k_10__pMek*(s__Erk_0 - s__pErk) - k_11*s__pErk
 
-----> Control variables:
-----> Observables:
	H1=s__pErk
 
-----> Initial conditions:
	[ 0, (k_4*k_6__Ras_0)/(k_4 + k_5), (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))), (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))), (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))]
 
-----> Parameters to be considered in the analysis:
	[ k_1, k_2, k_9, k_11]
 



Report inputs elapsed time: 0.22418
*******************************
-> COMPUTE LIE DERIVATIVES
*******************************

COMPUTING LIE DERIVATIVES OF ORDER 1
.................................................................
   ->The rank of the Jacobian generated by 1 derivatives is  1.
   ->The rank of the next Jacobian is expected to be maximum 2.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 2
   
.................................................................
   ->The rank of the Jacobian generated by 2 derivatives is  1.
   ->The rank of the next Jacobian is expected to be maximum 2.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 3
   
.................................................................
   ->The rank of the Jacobian generated by 3 derivatives is  1.
   ->The rank of the next Jacobian is expected to be maximum 2.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 4
   
.................................................................
   ->The rank of the Jacobian generated by 4 derivatives is  1.
   ->The rank of the next Jacobian is expected to be maximum 2.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 5
   
.................................................................
   ->The rank of the Jacobian generated by 5 derivatives is  2.
   ->The rank of the next Jacobian is expected to be maximum 3.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 6
   
.................................................................
   ->The rank of the Jacobian generated by 6 derivatives is  3.
   ->The rank of the next Jacobian is expected to be maximum 4.
.................................................................
  
COMPUTING LIE DERIVATIVES OF ORDER 7
   
.................................................................
   ->The rank of the Jacobian generated by 7 derivatives is 4.
Compute Lie derivatives elapsed time: 10.0994


***************************************
-> COMPUTE IDENTIFIABILITY TABLEAU
***************************************

 ----->The rank of the full Jacobian matrix is 4 

 ---->THE RANK OF THE FULL JACOBIAN IS COMPLETE, THUS AT LEAST LOCAL IDENTIFIABILITY IS GUARANTEED.
Compute tableau elapsed time: 8.7656


************************************************
-> COMPUTE REDUCED IDENTIFIABILITY TABLEAUS
************************************************


*****************************************************
-> THE RELATIONS NEEDED FOR COMPUTING THE PARAMETERS
*****************************************************

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                                                                                                                                                                                                                            ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - c2 - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - c3 + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))
 ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*NGF_0*k_1*k_3__TrkA_0*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 8*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (3*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) - c4 - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 6*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(3*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - NGF_0*k_1*k_3__TrkA_0*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 8*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 6*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - 3*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) + NGF_0*k_1*k_3__TrkA_0*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_2 + NGF_0*k_1)*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (3*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (2*NGF_0*k_1*k_3__TrkA_0*s_K^(2*n)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)
 
Compute reduced tableau  elapsed time: 20.0705


******************************************************************************************
-> DETECT (DIRECT) STRUCTURALLY GLOBALLY IDENTIFIABLE PARAMETERS AND REORGANIZES TABLEAU
*******************************************************************************************



 -> STRUCTURALLY GLOBALLY IDENTIFIABLE PARAMETERS DETERMINED DIRECTLY 
   (parameters corresponding to one non-zero element in the reduced identifiability tableau)



************************************************************************************************************
->THE REMAINING PARAMETERS (APART FROM IDENTIFIABLE OR NON-IDENTIFIABLE), AND THE CORRESPONDING RELATIONS  
************************************************************************************************************

-----> Parameters: 
[ k_1, k_2, k_9, k_11]
 
-----> Relations: 
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  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                                                                                                                                                                                                                            ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - c2 - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - c3 + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))
 ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*NGF_0*k_1*k_3__TrkA_0*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 8*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (3*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) - c4 - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 6*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(3*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4 + k_5)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (8*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (8*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (12*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (12*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - NGF_0*k_1*k_3__TrkA_0*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (NGF_0*k_1*k_3__TrkA_0*n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_4 + k_5)*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 8*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (2*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 6*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - 3*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (3*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(4*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (10*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (10*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 4*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (6*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (2*k_10__Mek_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_5*k_6__Ras_0)/(k_4 + k_5) - (3*k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (3*k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (10*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (10*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) + (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (3*k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (3*k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*k_9 + 6*k_11 + (6*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(6*s__Erk_0 - (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + 2*k_9 + 3*k_11 - 3*k_10__Mek_0 + (k_4*k_6__Ras_0)/(k_4 + k_5) + (2*k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (6*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + NGF_0*k_1*k_3__TrkA_0*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n))) + NGF_0*k_1*k_3__TrkA_0*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((2*n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (2*n^2*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(2*n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^3 - (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(n - 1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 2))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2 + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2) - ((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_2 + NGF_0*k_1)*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + ((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(((s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(((s_K^n*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (n*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^(n - 1))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s_K^n*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (3*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) + (s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_2 + NGF_0*k_1)*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)) + (s_K^n*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 3*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^2 - (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + 2*k_11 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))) + ((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (2*s__Erk_0 - (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (2*k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (2*k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) + (k_4 + k_5)*((k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(k_4 + k_5) - (k_4*k_7*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*((k_4*k_6__Ras_0*k_8__Raf_0*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))) - (k_4*k_9*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))))/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - (k_4*k_11*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) + (k_4 + k_5)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))) - 2*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_4*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5)) - (k_4*k_5*k_6__Ras_0)/(k_4 + k_5))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))) - (NGF_0*k_1*k_3__TrkA_0*s_K^n*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n) - (2*NGF_0*k_1*k_3__TrkA_0*s_K^(2*n)*(s__Erk_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_6__Ras_0 - (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_10__Mek_0 - (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_8__Raf_0 - (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5)))))/(s_K^n + ((k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0*s__Erk_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_11 + (k_4*k_6__Ras_0*k_8__Raf_0*k_10__Mek_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))*(k_9 + (k_4*k_6__Ras_0*k_8__Raf_0)/((k_4 + k_5)*(k_7 + (k_4*k_6__Ras_0)/(k_4 + k_5))))))^n)^2)
 
-----> THE SYMBOLIC SOLUTION OF THE REMAINING PARAMETERS: 
[Warning: Cannot find explicit solution.] 
[> In <a href="matlab:matlab.internal.language.introspective.errorDocCallback('solve', 'C:\Program Files\MATLAB\R2016b\toolbox\symbolic\symbolic\solve.m', 316)" style="font-weight:bold">solve</a> (<a href="matlab: opentoline('C:\Program Files\MATLAB\R2016b\toolbox\symbolic\symbolic\solve.m',316,0)">line 316</a>)
  In <a href="matlab:matlab.internal.language.introspective.errorDocCallback('genssiOrderTableau>solveRemPar', 'D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiOrderTableau.m', 682)" style="font-weight:bold">genssiOrderTableau>solveRemPar</a> (<a href="matlab: opentoline('D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiOrderTableau.m',682,0)">line 682</a>)
  In <a href="matlab:matlab.internal.language.introspective.errorDocCallback('genssiOrderTableau', 'D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiOrderTableau.m', 216)" style="font-weight:bold">genssiOrderTableau</a> (<a href="matlab: opentoline('D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiOrderTableau.m',216,0)">line 216</a>)
  In <a href="matlab:matlab.internal.language.introspective.errorDocCallback('genssiMain', 'D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiMain.m', 87)" style="font-weight:bold">genssiMain</a> (<a href="matlab: opentoline('D:\data\Tom\Research\Raedler\mRNA-Helmholtz\Tom\GenSSI\genssiMain.m',87,0)">line 87</a>)] 
-----> The parameter k_1 has the solution/solutions: 
  matrix(0, 1, [])
-----> The parameter k_2 has the solution/solutions: 
  matrix(0, 1, [])
-----> The parameter k_9 has the solution/solutions: 
  matrix(0, 1, [])
-----> The parameter k_11 has the solution/solutions: 
  matrix(0, 1, [])
Order tableau elapsed time: 221.0068


***************************************************************

 -----> THE MODEL IS STRUCTURALLY LOCALLY IDENTIFIABLE 

***************************************************************

        The structurally globally identifiable parameters are: 

         	None

        The structurally locally identifiable parameters are: 

     	[      k_1	      k_2	      k_9	      k_11	]


Report results elapsed time: 0.020948
Total elapsed time: 260.1948
