PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Takamatsu, H.* ; Takegahara, N.* ; Nakagawa, Y.* ; Tomura, M.* ; Taniguchi, M.* ; Friedel, R.H. ; Rayburn, H.* ; Tessier-Lavigne, M.* ; Yoshida, Y.* ; Okuno, T.* ; Mizui, M.* ; Kang, S.* ; Nojima, S.* ; Tsujimura, T.* ; Nakatsuji, Y.* ; Katayama, I.* ; Toyofuku, T.* ; Kikutani, H.* ; Kumanogoh, A.*

Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.

Nat. Immunol. 11, 594-560 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The recirculation of leukocytes is essential for proper immune responses. However, the molecular mechanisms that regulate the entry of leukocytes into the lymphatics remain unclear. Here we show that plexin-A1, a principal receptor component for class III and class VI semaphorins, was crucially involved in the entry of dendritic cells (DCs) into the lymphatics. Additionally, we show that the semaphorin Sema3A, but not Sema6C or Sema6D, was required for DC transmigration and that Sema3A produced by the lymphatics promoted actomyosin contraction at the trailing edge of migrating DCs. Our findings not only demonstrate that semaphorin signals are involved in DC trafficking but also identify a previously unknown mechanism that induces actomyosin contraction as these cells pass through narrow gaps.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
4.460
4.460
74
151
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Leukocyte migration; Langerhans cells; Nodes; Plexin-A1; Integrin; Roles; Actin; Skin; Morphogenesis; Regeptiors
Sprache
Veröffentlichungsjahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Quellenangaben Band: 11, Heft: 7, Seiten: 594-560 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500500-001
DOI 10.1038/ni.1885
Scopus ID 77953808714
PubMed ID 20512151
Erfassungsdatum 2010-09-08
[➜Korrektur melden]