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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A mechanistic model for medulloblastoma induction in mice.
Radiat. Res. 179, 610-614 (2013)
Verlagsversion
DOI
PMC
Medulloblastomas in Patched heterozygous mice (Ptc1(+/-) mice) are induced with high probability by ionizing radiation applied in the immediate post-natal period. A mathematical model is described here that accommodates the dependence of the medulloblastoma incidence on dose, age at exposure and age. The model assumes that the first step in the development of the cancer is already present in all cells of the patched mouse due to germ-line inactivation of one allele of the patched tumor suppressor gene. The subsequent rate-limiting step is dependent linearly on dose at least up to 3 Gy. The observed strong decrease in carcinogenic effect of radiation between exposure on day 1 and day 10 is described by a physiological elimination of target cells during post-natal maturation of the brain. A single malignant cell develops into a tumor following a gamma-distribution with mean of about 160 days. The multiplicity of medulloblastomas is predicted.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.689
1.326
3
3
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Lung-cancer; Mutation; Carcinogenesis; Radon; Cells; Risk
Sprache
englisch
Veröffentlichungsjahr
2013
HGF-Berichtsjahr
2013
ISSN (print) / ISBN
0033-7587
e-ISSN
1938-5404
Zeitschrift
Radiation Research
Quellenangaben
Band: 179,
Heft: 5,
Seiten: 610-614
Verlag
Radiation Research Society
Verlagsort
Lawrence
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Biology (ISB)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-500200-001
PubMed ID
23560628
DOI
10.1667/RR3130.1
WOS ID
WOS:000330985900012
Scopus ID
84877000608
Erfassungsdatum
2013-07-31