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Marcon, A.* ; Cerveri, I.* ; Wjst, M. ; Anto, J.* ; Heinrich, J. ; Janson, C.* ; Jarvis, D.* ; Leynaert, B.* ; Probst-Hensch, N.* ; Svanes, C.* ; Torén, K.* ; Burney, P.* ; de Marco, R.*

Can an airway challenge test predict respiratory diseases? A population-based international study.

J. Allergy Clin. Immunol. 133, 104-110 (2014)
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BACKGROUND: Evidence on the longitudinal association of airway responsiveness with respiratory diseases is scarce. The best indicator of responsiveness is still undetermined. OBJECTIVE: We investigated the association of airway responsiveness with the incidence of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. METHODS: We studied 3851 subjects who underwent spirometry and methacholine challenge tests both at baseline (1991-1993), when they were 20 to 44 years old, and at follow-up (1999-2002) in the European Community Respiratory Health Survey. Airway responsiveness was defined based on the methacholine dose-response slope on both occasions. Incidence rate ratios for the association of airway responsiveness with disease occurrence were computed by using Poisson regression. RESULTS: With respect to reference (slope of the fourth quintile or greater), subjects with the greatest degree of airway responsiveness (slope less than the first quintile) showed the greatest risk of developing asthma, COPD, and allergic rhinitis (incidence rate ratios of 10.82, 5.53, and 4.84, respectively; all P < .01). A low slope predicted disease occurrence, even in subjects who did not reach a 20% decrease in FEV1 at the cumulative dose of 1 mg of methacholine (PD20 >1 mg). A decrease in slope over time was an independent predictor of disease risk. CONCLUSION: Airway responsiveness predicted new-onset asthma, COPD, and allergic rhinitis. Our study supports the use of a continuous noncensored indicator of airway responsiveness, such as the slope of the methacholine dose-response curve, in clinical practice and research because it showed clear advantages over PD20.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Airway hyperresponsiveness; Airflow obstruction; Allergic rhinitis; Asthma; European Community Respiratory Health Survey; Chronic obstructive pulmonary disease; Obstructive Pulmonary-disease; Dose-response Curves; Bronchial Hyperresponsiveness; Health-survey; Allergic Rhinitis; Young-adults; Risk-factors; Asthma; Copd; Cohort
Sprache englisch
Veröffentlichungsjahr 2014
Prepublished im Jahr 2013
HGF-Berichtsjahr 2013
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Zeitschrift The journal of allergy and clinical immunology
Quellenangaben Band: 133, Heft: 1, Seiten: 104-110 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
POF Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Lung Research
Genetics and Epidemiology
PSP-Element(e) G-505000-003
G-503900-001
PubMed ID 23683511
DOI 10.1016/j.jaci.2013.03.040
WOS ID WOS:000329105700014
Scopus ID 84891739960
Erfassungsdatum 2013-07-31
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