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Karrasch, S.* ; Ernst, K.* ; Behr, J.* ; Heinrich, J. ; Huber, R.M.* ; Nowak, D.* ; Wichmann, H.-E. ; Baumeister, S.E. ; Meisinger, C. ; Ladwig, K.-H. ; Holle, R. ; Jörres, R.A.* ; Schulz, S. ; KORA Study Group (Wichmann, H.-E. ; Holle, R. ; John, J. ; Illig, T. ; Peters, A. ; Meisinger, C. ; Ladwig, K.-H.)

Exhaled nitric oxide and influencing factors in a random population sample.

Respir. Med. 105, 713-718 (2011)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The aim of the current study was to determine the impact and interaction of important influencing factors on the fraction of exhaled nitric oxide (FeNO). FeNO was measured in a population-based sample of 1250 middle-aged subjects from the KORA F4 cohort (Augsburg, Germany). Analysis of covariance models was performed including the factors age, height, FVC, FEV(1), sex, current smoking status, recent respiratory tract infection, and respiratory allergy. Geometric mean (SD as factor; 95% confidence interval as factor) FeNO was 13.9 (1.9; 1.033) ppb. FeNO significantly depended on age, height, smoking, infection and allergy. Smoking reduced FeNO by 21%, while infection and allergy led to increases by 9 and 11%, respectively. Increases in age by 10 years and in height by 10 cm were associated with increases of FeNO by 15 and 10%, respectively. Non-smokers demonstrated independent multiplicative superposition of factors affecting FeNO while the effect of allergy was virtually eliminated in smokers without infection. We conclude that in middle-aged non-smokers the effects of infection, age and height can be easily taken into account and do not significantly disturb the effect of respiratory tract allergies on FeNO. In current smokers, however, effects were heterogeneous and information on smoking intensity seems to be useful for better adjustment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Fraction of exhaled nitric oxide; Age; Height; Respiratory tract allergy; Respiratory tract infection; Smoking
Sprache englisch
Veröffentlichungsjahr 2011
Prepublished im Jahr 2010
HGF-Berichtsjahr 2010
ISSN (print) / ISBN 0954-6111
e-ISSN 1532-3064
Zeitschrift Respiratory Medicine
Quellenangaben Band: 105, Heft: 5, Seiten: 713-718 Artikelnummer: , Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute of Health Economics and Health Care Management (IGM)
POF Topic(s) 30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Lung Research
Genetics and Epidemiology
PSP-Element(e) G-505000-001
G-503900-001
G-505300-002
G-504090-001
PubMed ID 21146387
DOI 10.1016/j.rmed.2010.11.002
WOS ID WOS:000289814000008
Scopus ID 79953025229
Erfassungsdatum 2010-12-31
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