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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Hyperthermia adds to chemotherapy.
Eur. J. Cancer 44, 2546-2554 (2008)
The hallmarks of hyperthermia and its pleotropic effects are in favour of its combined use with chemotherapy. Preclinical research reveals that for heat killing and synergistic effects the thermal dose is most critical. Thermal enhancement of drug cytotoxicity is accompanied by cellular death and necrosis without increasing its oncogenic potential. The induction of genetically defined stress responses can deliver danger signals to activate the host's immune system. The positive results of randomised trials have definitely established hyperthermia in combination with chemotherapy as a novel clinical modality for the treatment of cancer. Hyperthermia targets the action of chemotherapy within the heated tumour region without affecting systemic toxicity. In specific clinical settings regional hyperthermia (RHT) or hyperthermic perfusion has proved its value and deserve a greater focus and investigation in other malignancies. In Europe, more specialised centres should be created and maintained as network of excellence for hyperthermia in the field of oncology.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Hyperthermia; Chemotherapy; HSP; Immunology; Liposomes; HIPEC; ILP
ISSN (print) / ISBN
0959-8049
e-ISSN
1879-0852
Zeitschrift
European Journal of Cancer
Quellenangaben
Band: 44,
Heft: 17,
Seiten: 2546-2554
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)