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Graef, P.* ; Buchholz, V.R.* ; Stemberger, C.* ; Flossdorf, M.* ; Henkel, L.* ; Schiemann, M. ; Drexler, I.* ; Höfer, T.* ; Riddell, S.R.* ; Busch, D.H.

Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8+ central memory T cells.

Immunity 41, 116-126 (2014)
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Maintenance of immunological memory has been proposed to rely on stem-cell-like lymphocytes. However, data supporting this hypothesis are focused on the developmental potential of lymphocyte populations and are thus insufficient to establish the functional hallmarks of stemness. Here, we investigated self-renewal capacity and multipotency of individual memory lymphocytes by in vivo fate mapping of CD8(+) T cells and their descendants across three generations of serial single-cell adoptive transfer and infection-driven re-expansion. We found that immune responses derived from single naive T (Tn) cells, single primary, and single secondary central memory T (Tcm) cells reached similar size and phenotypic diversity, were subjected to comparable stochastic variation, and could ultimately reconstitute immunocompetence against an otherwise lethal infection with the bacterial pathogen Listeria monocytogenes. These observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell compartment and highlight the promising therapeutic potential of this immune cell subset.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2014
HGF-Berichtsjahr 2014
ISSN (print) / ISBN 1074-7613
e-ISSN 1097-4180
Zeitschrift Immunity
Quellenangaben Band: 41, Heft: 1, Seiten: 116-126 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
Institute of Virology (VIRO)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501790-003
G-520100-001
PubMed ID 25035956
DOI 10.1016/j.immuni.2014.05.018
WOS ID WOS:000341444200015
Erfassungsdatum 2014-07-20
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