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A review of standardized metabolic phenotyping of animal models.
Mamm. Genome 25, 497-507 (2014)
Metabolic phenotyping of genetically modified animals aims to detect new candidate genes and related metabolic pathways that result in dysfunctional energy balance regulation and predispose for diseases such as obesity or type 2 diabetes mellitus. In this review, we provide a comprehensive overview on the technologies available to monitor energy flux (food uptake, bomb calorimetry of feces and food, and indirect calorimetry) and body composition (qNMR, DXA, and MRI) in animal models for human diseases with a special focus on phenotyping methods established in genetically engineered mice. We use an energy flux model to illustrate the principles of energy allocation, describe methodological aspects how to monitor energy balance, and introduce strategies for data analysis and presentation.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
2.883
0.826
13
12
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Indirect Calorimetry; Body-composition; Energy-intake; Magnetic-resonance; Insulin-resistance; Adipose-tissue; Mice; Obesity; Mouse; Diet
Sprache
englisch
Veröffentlichungsjahr
2014
HGF-Berichtsjahr
2014
ISSN (print) / ISBN
0938-8990
e-ISSN
1432-1777
Zeitschrift
Mammalian Genome
Quellenangaben
Band: 25,
Heft: 9,
Seiten: 497-507
Verlag
Springer
Verlagsort
New York
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)
POF Topic(s)
30201 - Metabolic Health
90000 - German Center for Diabetes Research
90000 - German Center for Diabetes Research
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-500600-003
G-500600-001
G-501900-063
G-501900-066
G-500600-001
G-501900-063
G-501900-066
PubMed ID
25199945
WOS ID
WOS:000342173700013
Scopus ID
84929517148
Erfassungsdatum
2014-09-11