PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Day, J.W.* ; Ottaway, N.* ; Patterson, J.T.* ; Gelfanov, V.* ; Smiley, D.* ; Gidda, J.* ; Findeisen, H.M.* ; Bruemmer, D.* ; Drucker, D.J.* ; Chaudhary, N.* ; Holland, J.* ; Hembree, J.* ; Abplanalp, W.* ; Grant, E.* ; Ruehl, J.* ; Wilson, H.* ; Kirchner, H.* ; Lockie, S.H.* ; Hofmann, S.* ; Woods, S.C.* ; Nogueiras, R.* ; Pfluger, P.T. ; Perez-Tilve, D.* ; DiMarchi, R.* ; Tschöp, M.H.*

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.

Nat. Chem. Biol. 5, 749-57 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We report the efficacy of a new peptide with agonism at the glucagon and GLP-1 receptors that has potent, sustained satiation-inducing and lipolytic effects. Selective chemical modification to glucagon resulted in a loss of specificity, with minimal change to inherent activity. The structural basis for the co-agonism appears to be a combination of local positional interactions and a change in secondary structure. Two co-agonist peptides differing from each other only in their level of glucagon receptor agonism were studied in rodent obesity models. Administration of PEGylated peptides once per week normalized adiposity and glucose tolerance in diet-induced obese mice. Reduction of body weight was achieved by a loss of body fat resulting from decreased food intake and increased energy expenditure. These preclinical studies indicate that when full GLP-1 agonism is augmented with an appropriate degree of glucagon receptor activation, body fat reduction can be substantially enhanced without any overt adverse effects.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
0.000
2.330
365
405
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1552-4450
e-ISSN 1552-4469
Zeitschrift Nature Chemical Biology
Quellenangaben Band: 5, Heft: 10, Seiten: 749-57 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Basingstoke
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Obesity (IDO)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Forschungsfeld(er) Helmholtz Diabetes Center
PSP-Element(e) G-501900-221
G-502200-001
PubMed ID 19597507
DOI 10.1038/nchembio.209
WOS ID 000270039900013
Erfassungsdatum 2009-07-13
[➜Korrektur melden]