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Salmons, B.* ; Günzburg, W.H.

Targeting of retroviral vectors for gene therapy.

Hum. Gene Ther. 4, 129-141 (1993)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Retroviral vectors are one of the most promising vehicles for the delivery of therapeutic genes in human gene therapy protocols. Retroviral-mediated gene transfer currently being used in human clinical trials is based upon ex vivo transduction of target cells. The ability to target the delivery and expression of therapeutic genes in vivo using retroviral vectors is a prerequisite for widespread and routine use in the clinic and will be of great importance for the safe and successful treatment of certain genetic disorders as well as tumors and viral infections. A number of approaches have been taken to develop retroviral vectors that are able to target particular cell types both at the level of the transduction event and at the level of expression. Using various combinations of the restrictive features reviewed in this article, it should be possible to achieve definitive targeting of genes transduced by retroviral vectors.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 1993
HGF-Berichtsjahr 0
ISSN (print) / ISBN 1043-0342
e-ISSN 1557-7422
Zeitschrift Human Gene Therapy. Clinical Development
Quellenangaben Band: 4, Heft: 2, Seiten: 129-141 Artikelnummer: , Supplement: ,
Verlag Mary Ann Liebert
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
DOI 10.1089/hum.1993.4.2-129
Scopus ID 0027312542
Erfassungsdatum 1993-12-31
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