Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Cholesterol modulates glycolipid conformation and receptor activity.
Nat. Chem. Biol. 7, 260-262 (2011)
We document a new dimension of surface recognition in which communication is controlled through the collective behavior of lipids. Membrane cholesterol induces a tilt in glycolipid receptor headgroup, resulting in loss of access for ligand binding. This property appears to organize erythrocyte blood group presentation and glycolipid receptor function during the activation of sperm fertility, suggesting that lipid 'allostery' is a means to regulate membrane recognition processes.
Impact Factor
Scopus SNIP
Scopus
Cited By
Cited By
Altmetric
0.000
3.043
162
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
0
ISSN (print) / ISBN
1552-4450
e-ISSN
1552-4469
Zeitschrift
Nature Chemical Biology
Quellenangaben
Band: 7,
Heft: 5,
Seiten: 260-262
Verlag
Nature Publishing Group
Verlagsort
Basingstoke
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)
PubMed ID
21460830
Erfassungsdatum
2011-12-31