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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The role of the complement system in metabolic organs and metabolic diseases.
Semin. Immunol. 25, 47-53 (2013)
Emerging evidence points to a close crosstalk between metabolic organs and innate immunity in the course of metabolic disorders. In particular, cellular and humoral factors of innate immunity are thought to contribute to metabolic dysregulation of the adipose tissue or the liver, as well as to dysfunction of the pancreas; all these conditions are linked to the development of insulin resistance and diabetes mellitus. A central component of innate immunity is the complement system. Interestingly, the classical view of complement as a major system of host defense that copes with infections is changing to that of a multi-functional player in tissue homeostasis, degeneration, and regeneration. In the present review, we will discuss the link between complement and metabolic organs, focusing on the pancreas, adipose tissue, and liver and the diverse effects of complement system on metabolic disorders.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Adipose Tissue ; Complement ; Diabetes ; Insulin Resistance ; Liver ; Pancreas ; Steatosis
ISSN (print) / ISBN
1044-5323
e-ISSN
1044-5323
Zeitschrift
Seminars in Immunology
Quellenangaben
Band: 25,
Heft: 1,
Seiten: 47-53
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Pancreatic Islet Research (IPI)