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Nettleton, J.A.* ; McKeown, N.M.* ; Kanoni, S.* ; Lemaitre, R.N.* ; Hivert, M.F.* ; Ngwa, J.S.* ; van Rooij, F.J.* ; Sonestedt, E.* ; Wojczynski, M.K.* ; Ye, Z.* ; Tanaka, T.* ; Garcia, M.* ; Anderson, J.S.* ; Follis, J.L.* ; Djousse, L.* ; Mukamal, K.J.* ; Papoutsakis, C.* ; Mozaffarian, D.* ; Zillikens, M.C.* ; Bandinelli, S.* ; Bennett, A.J.* ; Borecki, I.B.* ; Feitosa, M.F.* ; Ferrucci, L.* ; Forouhi, N.G.* ; Groves, C.J.* ; Hallmans, G.* ; Harris, T.* ; Hofman, A.* ; Houston, D.K.* ; Hu, F.B.* ; Johansson, I.* ; Kritchevsky, S.B.* ; Langenberg, C.* ; Launer, L.* ; Liu, Y.* ; Loos, R.J.* ; Nalls, M.* ; Orho-Melander, M.* ; Renström, F.* ; Rice, K.* ; Risérus, U.* ; Rolandsson, O.* ; Rotter, J.I.* ; Saylor, G.* ; Sijbrands, E.J.* ; Sjogren, P.* ; Smith, A.* ; Steingrímsdóttir, L.* ; Uitterlinden, A.G.* ; Wareham, N.J.* ; Prokopenko, I.* ; Pankow, J.S.* ; van Duijn, C.M.* ; Florez, J.C* ; Witteman, J.C.* ; Dupuis, J.* ; Dedoussis, G.V.* ; Ordovas, J.M.* ; Ingelsson, E.* ; Cupples, L.A.* ; Siscovick, D.S.* ; Franks, P.W.* ; Meigs, J.B.*

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies.

Diabetes Care 33, 2684-2691 (2010)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS: Via meta-analysis of data from 14 cohorts comprising ∼ 48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS: Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele. CONCLUSIONS: Our results support the favorable association of whole-grain intake with fasting glucose and insulin and suggest a potential interaction between variation in GCKR and whole-grain intake in influencing fasting insulin concentrations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Zeitschrift Diabetes Care
Quellenangaben Band: 33, Heft: 12, Seiten: 2684-2691 Artikelnummer: , Supplement: ,
Verlag American Diabetes Association
Verlagsort Alexandria, Va.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Pancreatic Islet Research (IPI)