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Buters, J.T.M. ; Prank, M.* ; Sofiev, M.* ; Pusch, G. ; Albertini, R.* ; Annesi-Maesano, I.* ; Antunes, C.* ; Behrendt, H. ; Berger, U.* ; Brandao, R.* ; Celenk, S.* ; Galan, C.* ; Grewling, L.* ; Jackowiak, B.* ; Kennedy, R.* ; Rantio-Lehtimaki, A.* ; Reese, G.* ; Sauliene, I.* ; Smith, M.* ; Thibaudon, M.* ; Weber, B.* ; Cecchi, L.*

Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season.

J. Allergy Clin. Immunol. 136, 87-95 (2015)
Verlagsversion DOI PMC
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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
BACKGROUND: Allergies to grass pollen are the number one cause of outdoor hay fever. The human immune system reacts with symptoms to allergen from pollen. OBJECTIVE: We investigated the natural variability in release of the major group 5 allergen from grass pollen across Europe. METHODS: Airborne pollen and allergens were simultaneously collected daily with a volumetric spore trap and a high-volume cascade impactor at 10 sites across Europe for 3 consecutive years. Group 5 allergen levels were determined with a Phl p 5-specific ELISA in 2 fractions of ambient air: particulate matter of greater than 10 μm in diameter and particulate matter greater than 2.5 μm and less than 10 μm in diameter. Mediator release by ambient air was determined in FcεRI-humanized basophils. The origin of pollen was modeled and condensed to pollen potency maps. RESULTS: On average, grass pollen released 2.3 pg of Phl p 5 per pollen. Allergen release per pollen (potency) varied substantially, ranging from less than 1 to 9 pg of Phl p 5 per pollen (5% to 95% percentile). The main variation was locally day to day. Average potency maps across Europe varied between years. Mediator release from basophilic granulocytes correlated better with allergen levels per cubic meter (r(2) = 0.80, P < .001) than with pollen grains per cubic meter (r(2) = 0.61, P < .001). In addition, pollen released different amounts of allergen in the non-pollen-bearing fraction of ambient air, depending on humidity. CONCLUSION: Across Europe, the same amount of pollen released substantially different amounts of group 5 grass pollen allergen. This variation in allergen release is in addition to variations in pollen counts. Molecular aerobiology (ie, determining allergen in ambient air) might be a valuable addition to pollen counting.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Allergen ; Europe ; Hialine ; Pm10 ; Pm2.5 ; Phl P 5 ; Silam ; Allergy ; Basophil ; Exposure ; Grass ; Modeling; Thunderstorm-related Asthma; Bet V 1; Birch Pollen; Create Project; Timothy Grass; Hay-fever; Release; Ige; Standardization; Sensitization
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Zeitschrift The journal of allergy and clinical immunology
Quellenangaben Band: 136, Heft: 1, Seiten: 87-95 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Allergy Research (IAF)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
PSP-Element(e) G-505400-001
DOI 10.1016/j.jaci.2015.01.049
WOS ID WOS:000357542200010
PubMed ID 25956508
Erfassungsdatum 2015-05-11
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