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Maier, H. ; Schütt, C. ; Steinkamp, R. ; Hurt, A. ; Schneltzer, E. ; Gormanns, P. ; Lengger, C. ; Griffiths, M.* ; Melvin, D.* ; Agrawal, N.* ; Alcantara, R.* ; Evans, A.* ; Gannon, D.* ; Holroyd, S.* ; Kipp, C.* ; Raj, N. P.* ; Richardson, D.* ; Leblanc, S.* ; Vasseur, L.* ; Masuya, H.* ; Kobayashi, K.* ; Suzuki, T.* ; Tanaka, N.* ; Wakana, S.* ; Walling, A.* ; Clary, D.* ; Gallegos, J.* ; Fuchs, H. ; Hrabě de Angelis, M. ; Gailus-Durner, V.

Principles and application of LIMS in mouse clinics.

Mamm. Genome 26, 467-481 (2015)
Verlagsversion Anhang DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Large-scale systemic mouse phenotyping, as performed by mouse clinics for more than a decade, requires thousands of mice from a multitude of different mutant lines to be bred, individually tracked and subjected to phenotyping procedures according to a standardised schedule. All these efforts are typically organised in overlapping projects, running in parallel. In terms of logistics, data capture, data analysis, result visualisation and reporting, new challenges have emerged from such projects. These challenges could hardly be met with traditional methods such as pen & paper colony management, spreadsheet-based data management and manual data analysis. Hence, different Laboratory Information Management Systems (LIMS) have been developed in mouse clinics to facilitate or even enable mouse and data management in the described order of magnitude. This review shows that general principles of LIMS can be empirically deduced from LIMS used by different mouse clinics, although these have evolved differently. Supported by LIMS descriptions and lessons learned from seven mouse clinics, this review also shows that the unique LIMS environment in a particular facility strongly influences strategic LIMS decisions and LIMS development. As a major conclusion, this review states that there is no universal LIMS for the mouse research domain that fits all requirements. Still, empirically deduced general LIMS principles can serve as a master decision support template, which is provided as a hands-on tool for mouse research facilities looking for a LIMS.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Zeitschrift Mammalian Genome
Quellenangaben Band: 26, Heft: 9-10, Seiten: 467-481 Artikelnummer: , Supplement: ,
Verlag Springer
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
POF Topic(s) 30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500600-001
G-500600-002
G-500692-001
PubMed ID 26208973
DOI 10.1007/s00335-015-9586-7
WOS ID WOS:000362893400012
Scopus ID 84943813758
Scopus ID 84937948535
Erfassungsdatum 2015-07-27
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