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Finkin, S.* ; Yuan, D.T. ; Stein, I.* ; Taniguchi, K.* ; Weber, A.* ; Unger, K. ; Browning, J.L.* ; Goossens, N.* ; Nakagawa, S.* ; Gunasekaran, G.* ; Schwartz, M.E.* ; Kobayashi, M.* ; Kumada, H.* ; Berger, M.* ; Pappo, O.* ; Rajewsky, K.* ; Hoshida, Y.* ; Karin, M.* ; Heikenwälder, M. ; Ben-Neriah, Y.* ; Pikarsky, E.*

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.

Nat. Immunol. 16, 1235-1244 (2015)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Ectopic lymphoid-like structures (ELSs) are often observed in cancer, yet their function is obscure. Although ELSs signify good prognosis in certain malignancies, we found that hepatic ELSs indicated poor prognosis for hepatocellular carcinoma (HCC). We studied an HCC mouse model that displayed abundant ELSs and found that they constituted immunopathological microniches wherein malignant hepatocyte progenitor cells appeared and thrived in a complex cellular and cytokine milieu until gaining self-sufficiency. The egress of progenitor cells and tumor formation were associated with the autocrine production of cytokines previously provided by the niche. ELSs developed via cooperation between the innate immune system and adaptive immune system, an event facilitated by activation of the transcription factor NF-κB and abolished by depletion of T cells. Such aberrant immunological foci might represent new targets for cancer therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Sprache englisch
Veröffentlichungsjahr 2015
HGF-Berichtsjahr 2015
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Quellenangaben Band: 16, Heft: 12, Seiten: 1235-1244 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)
Translational Metabolic Oncology (IDC-TMO)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
Forschungsfeld(er) Immune Response and Infection
Radiation Sciences
PSP-Element(e) G-551600-001
G-501000-001
PubMed ID 26502405
DOI 10.1038/ni.3290
WOS ID WOS:000365062100007
Scopus ID 84947863720
Erfassungsdatum 2015-11-11
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