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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The multi-modal immune pathogenesis of atopic eczema.
Trends Immunol. 36, 788–801 (2015)
Atopic eczema (AE) is one of the most common inflammatory diseases, often constituting a lifelong burden for afflicted individuals. Recent findings have provided new insights into the pathogenesis of AE, revealing contributions of genetics, skin microbiota, and both innate and adaptive immunity in disease onset and progression. We review these findings here, assembling contributing factors conceptually into four modules that can interact in various ways to ultimately lead to epidermal barrier impairment, unchecked type 2 immunity, and chronic disease. We present this modular framework as a basis for understanding the varied presentations of AE, and in this context we propose a diagnostic and therapeutic algorithm aimed at the precise stratification of AE patients and the implementation of individualized medicine in AE standard of care.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Zeitschrift
Trends in Immunology
Quellenangaben
Band: 36,
Heft: 12,
Seiten: 788–801
Verlag
Elsevier
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Allergy Research (IAF)