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Rodriguez-Terrones, D. ; Torres-Padilla, M.E.

Nimble and ready to mingle: Transposon outbursts of early development.

Trends Genet. 34, 806-820 (2018)
DOI PMC
Transposable elements are the largest individual constituent of mammalian genomes. These elements are highly diverse, a consequence of the multiplicity of genomic habitats that they inhabit and of the complex evolutionary histories that they have developed therein. Intriguingly, a surge of transposable element transcription occurs during mammalian preimplantation development, contributing to the establishment of totipotency and pluripotency and to the activation of the embryonic genome. However, it remains an open question how such an evolutionarily divergent set can mediate such conserved developmental processes. Here, we review transposable element diversity across mammals and their evolutionary significance. We also discuss the implications that their high evolutionary divergence has for the regulation of preimplantation development across mammals.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Cellular Plasticity ; Evolutionary Genomics ; Genome Architecture ; Pluripotency ; Totipotency ; Transposons; Bat Myotis-lucifugus; Rolling-circle Transposons; Endogenous Retroviruses; Preimplantation Embryos; Placental Mammals; Dna Transposons; Evolutionary Dynamics; Eukaryotic Genomes; Line-1 Activity; Ribosomal-rna
Sprache englisch
Veröffentlichungsjahr 2018
HGF-Berichtsjahr 2018
ISSN (print) / ISBN 0168-9479
Zeitschrift Trends in Genetics
Quellenangaben Band: 34, Heft: 10, Seiten: 806-820 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 84 Theobalds Rd, London Wc1x 8rr, England
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epigenetics and Stem Cells (IES)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Stem Cell and Neuroscience
PSP-Element(e) G-506200-001
DOI 10.1016/j.tig.2018.06.006
WOS ID WOS:000445026600007
Scopus ID 85050397344
PubMed ID 30057183
Erfassungsdatum 2018-08-01
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