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Kamies, R. ; Martinez Jimenez, C.P.

Advances of single-cell genomics and epigenomics in human disease: Where are we now?

Mamm. Genome 31, 170-180 (2020)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Cellular heterogeneity is revolutionizing the way to study, monitor and dissect complex diseases. This has been possible with the technological and computational advances associated to single-cell genomics and epigenomics. Deeper understanding of cell-to-cell variation and its impact on tissue function will open new avenues for early disease detection, accurate diagnosis and personalized treatments, all together leading to the next generation of health care. This review focuses on the recent discoveries that single-cell genomics and epigenomics have facilitated in the context of human health. It highlights the potential of single-cell omics to further advance the development of personalized treatments and precision medicine in cancer, diabetes and chronic age-related diseases. The promise of single-cell technologies to generate new insights about the differences in function between individual cells is just emerging, and it is paving the way for identifying biomarkers and novel therapeutic targets to tackle age, complex diseases and understand the effect of life style interventions and environmental factors.
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2.287
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5
3
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Rna-seq; Translational Genomics; Gene-expression; Stem-cells; Alpha Cell; Mouse; Cancer; Transcriptomics; Health; Organization
Sprache englisch
Veröffentlichungsjahr 2020
HGF-Berichtsjahr 2020
ISSN (print) / ISBN 0938-8990
e-ISSN 1432-1777
Zeitschrift Mammalian Genome
Quellenangaben Band: 31, Heft: 5-6, Seiten: 170-180 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort One New York Plaza, Suite 4600, New York, Ny, United States
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Pioneer Campus (HPC)
POF Topic(s) 30204 - Cell Programming and Repair
Forschungsfeld(er) Pioneer Campus
PSP-Element(e) G-510005-001
DOI 10.1007/s00335-020-09834-4
WOS ID WOS:000549715400006
Scopus ID 85083401476
PubMed ID 32270277
Erfassungsdatum 2020-05-27
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