PuSH - Publikationsserver des Helmholtz Zentrums München: Diabetic polyneuropathy is associated with pathomorphological changes in human dorsal root ganglia: A study using 3T MR neurography.

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Jende, J.M.E.* ; Kender, Z.* ; Rother, C.* ; Alvarez-Ramos, L.* ; Groener, J.B.* ; Pham, M.* ; Morgenstern, J.* ; Oikonomou, D.* ; Hahn, A.* ; Juerchott, A.* ; Kollmer, J.* ; Heiland, S.* ; Kopf, S.* ; Nawroth, P.P. ; Bendszus, M.* ; Kurz, F.T.*

Diabetic polyneuropathy is associated with pathomorphological changes in human dorsal root ganglia: A study using 3T MR neurography.

Front. Neurosci. 14:570744 (2020)

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Diabetic neuropathy (DPN) is one of the most severe and yet most poorly understood complications of diabetes mellitus.In vivoimaging of dorsal root ganglia (DRG), a key structure for the understanding of DPN, has been restricted to animal studies. These have shown a correlation of decreased DRG volume with neuropathic symptom severity. Our objective was to investigate correlations of DRG morphology and signal characteristics at 3 Tesla (3T) magnetic resonance neurography (MRN) with clinical and serological data in diabetic patients with and without DPN. In this cross-sectional study, participants underwent 3T MRN of both L5 DRG using an isotropic 3D T2-weighted, fat-suppressed sequence with subsequent segmentation of DRG volume and analysis of normalized signal properties. Overall, 55 diabetes patients (66 +/- 9 years; 32 men; 30 with DPN) took part in this study. DRG volume was smaller in patients with severe DPN when compared to patients with mild or moderate DPN (134.7 +/- 21.86 vs 170.1 +/- 49.22;p= 0.040). In DPN patients, DRG volume was negatively correlated with the neuropathy disability score (r= -0.43; 95%CI = -0.66 to -0.14;p= 0.02), a measure of neuropathy severity. DRG volume showed negative correlations with triglycerides (r= -0.40; 95%CI = -0.57 to -0.19;p= 0.006), and LDL cholesterol (r= -0.33; 95%CI = -0.51 to -0.11;p= 0.04). There was a strong positive correlation of normalized MR signal intensity (SI) with the neuropathy symptom score in the subgroup of patients with painful DPN (r= 0.80; 95%CI = 0.46 to 0.93;p= 0.005). DRG SI was positively correlated with HbA1c levels (r= 0.30; 95%CI = 0.09 to 0.50;p= 0.03) and the triglyceride/HDL ratio (r= 0.40; 95%CI = 0.19 to 0.57;p= 0.007). In this firstin vivostudy, we found DRG morphological degeneration and signal increase in correlation with neuropathy severity. This elucidates the potential importance of MR-based DRG assessments in studying structural and functional changes in DPN.

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