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Return to homeostasis: Downregulation of NF-κB responses.
Nat. Immunol. 12, 709-714 (2011)
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
3.101
3.101
137
239
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
t-cell-activation; alpha-mediated phosphorylation; negative feedback loop; editing enzyme a20; ikk-alpha; irak-m; deubiquitinating enzyme; gene-expression; innate immunity; signaling pathway
Sprache
englisch
Veröffentlichungsjahr
2011
HGF-Berichtsjahr
2011
ISSN (print) / ISBN
1529-2908
e-ISSN
1529-2916
Zeitschrift
Nature Immunology
Quellenangaben
Band: 12,
Heft: 8,
Seiten: 709-714
Verlag
Nature Publishing Group
Verlagsort
New York, NY, USA
Begutachtungsstatus
Peer reviewed
PSP-Element(e)
G-505291-001
PubMed ID
21772279
DOI
10.1038/ni.2055
Scopus ID
80051982064
Erfassungsdatum
2011-11-10