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Peng, Y.* ; Felce, S.L.* ; Dong, D.* ; Penkava, F.* ; Mentzer, A.J.* ; Yao, X.* ; Liu, G.* ; Yin, Z.* ; Chen, J.L.* ; Lu, Y.* ; Wellington, D.* ; Wing, P.A.C.* ; Dominey-Foy, D.C.C.* ; Jin, C.* ; Wang, W.* ; Hamid, M.A.* ; Fernandes, R.A.* ; Wang, B.* ; Fries, A.* ; Zhuang, X.* ; Ashley, N.* ; Rostron, T.* ; Waugh, C.* ; Sopp, P.* ; Hublitz, P.* ; Beveridge, R.* ; Tan, T.K.* ; Dold, C.* ; Kwok, A.J.* ; Rich-Griffin, C.* ; Dejnirattisa, W.* ; Liu, C.* ; Kurupati, P.* ; Nassiri, I.* ; Watson, R.A.* ; Tong, O.* ; Taylor, C.A.* ; Kumar Sharma, P.* ; Sun, B.* ; Curion, F. ; Revale, S.* ; Garner, L.C.* ; Jansen, K.* ; Ferreira, R.C.* ; Attar, M.* ; Fry, J.W.* ; Russell, R.A.* ; COMBAT Consortium* ; Stauss, H.J.* ; James, W.* ; Townsend, A.J.* ; Ho, J.-P.* ; Klenerman, P.* ; Mongkolsapaya, J.* ; Screaton, G.R.* ; Dendrou, C.* ; Sansom, S.N.* ; Bashford-Rogers, R.* ; Chain, B.* ; Smith, G.L.* ; McKeating, J.A.* ; Fairfax, B.P.* ; Bowness, P.* ; McMichael, A.J.* ; Ogg, G.* ; Knight, J.C.* ; Dong, T.*

An immunodominant NP105-113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease.

Nat. Immunol., DOI: 10.1038/s41590-021-01084-z (2021)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
NP105-113-B*07:02-specific CD8+ T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105-113-B*07:02-specific T cell clones and single-cell sequencing were performed concurrently, with functional avidity and antiviral efficacy assessed using an in vitro SARS-CoV-2 infection system, and were correlated with T cell receptor usage, transcriptome signature and disease severity (acute n = 77, convalescent n = 52). We demonstrated a beneficial association of NP105-113-B*07:02-specific T cells in COVID-19 disease progression, linked with expansion of T cell precursors, high functional avidity and antiviral effector function. Broad immune memory pools were narrowed postinfection but NP105-113-B*07:02-specific T cells were maintained 6 months after infection with preserved antiviral efficacy to the SARS-CoV-2 Victoria strain, as well as Alpha, Beta, Gamma and Delta variants. Our data show that NP105-113-B*07:02-specific T cell responses associate with mild disease and high antiviral efficacy, pointing to inclusion for future vaccine design.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Rna-seq; Sars-cov-2; Recombinant
Sprache englisch
Veröffentlichungsjahr 2021
HGF-Berichtsjahr 2021
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Zeitschrift Nature Immunology
Verlag Nature Publishing Group
Verlagsort Heidelberger Platz 3, Berlin, 14197, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Computational Biology (ICB)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Enabling and Novel Technologies
PSP-Element(e) G-503800-001
Förderungen Cancer Research UK
UK Medical Research Council (MRC)
Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS), China
National Institutes of Health, National Key R&D Program of China
China Scholarship Council
NIHR Oxford Biomedical Research Centre
Schmidt Futures
National Institute for Health Research (NIHR) (UKRIDHSC COVID-19 Rapid Response Rolling Call)
Huo Family Foundation
UK-CIC
DHSC (PITCH)
Wellcome Investigator Award
UK MRC
Oxford Biomedical Research Centre
UK RI
DOI 10.1038/s41590-021-01084-z
WOS ID WOS:000724647800001
Scopus ID 85120634509
PubMed ID 34853448
Erfassungsdatum 2021-12-10
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