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Strieker, S.* ; Weinmann, T.* ; Gerlich, J.* ; von Mutius, E. ; Nowak, D.* ; Radon, K.* ; Wengenroth, L.*

Farm living and allergic rhinitis from childhood to young adulthood - prospective results of the GABRIEL study.

J. Allergy Clin. Immunol. 150, 1209-1215.e2 (2022)
Verlagsversion DOI PMC
Open Access Hybrid
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BACKGROUND: Growing up on a farm is associated with a reduced prevalence of respiratory allergies in childhood. It is unknown whether this protective effect remains into adulthood. OBJECTIVES: We aimed to prospectively investigate the relationship between farm exposure and prevalence of allergic rhinitis and wheeze from childhood to early adulthood. METHODS: Participants from phase 2 of the GABRIEL (Multidisciplinary Study to Identify the Genetic and Environmental Causes of Asthma in the European Community) study living in southern Germany (aged 6-11 years at baseline; 20-25 at follow-up) were invited to complete a questionnaire on sociodemographic data, farm contact, respiratory symptoms, and potential confounders. Odds ratios (OR) with 95% confidence intervals (95% CI) were modelled using generalized estimating equations (GEE). RESULTS: Of the 2,276 phase 2 participants, 1,501 (66%) answered the follow-up questionnaire of which 1,333 could be included in the analyses. Living on a farm was associated with reduced prevalence of allergic rhinitis (persistent farm living OR 0.4; 95% CI 0.2-0.6; only baseline farm living 0.4; 0.2-0.8). The odds ratio for developing symptoms from baseline to follow-up was almost three (OR 2.7; 95% CI 2.1-3.3), irrespective of farm living. For symptoms of wheeze, no statistically significant association with farm living was observed. CONCLUSIONS: The protective effect of farm living on allergic rhinitis persists from childhood to early adulthood. Continuing exposure over puberty does not add to the effect. This confirms that the window of opportunity for a protective effect might be found in childhood.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Asthma ; Allergic Rhinitis ; Farming ; Prospective Cohort Study ; Rural Environment ; Young Adulthood; Asthma; Exposure; Atopy; Prevalence; Symptoms; Environments; Protection; Diseases; Children; Isaac
Sprache englisch
Veröffentlichungsjahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Zeitschrift The journal of allergy and clinical immunology
Quellenangaben Band: 150, Heft: 5, Seiten: 1209-1215.e2 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Asthma and Allergy Prevention (IAP)
Institute of Lung Health and Immunity (LHI)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Allergy
Lung Research
PSP-Element(e) G-503300-001
G-501600-001
Förderungen European Research Council Advanced Investigators Grant
European Commission as part of GABRIEL
Association for the Promotion of Science and Research at the Medical Faculty, Ludwig Maximilian University of Munich
DOI 10.1016/j.jaci.2022.05.027
WOS ID 000962767400007
Scopus ID 85135320939
PubMed ID 35779667
Erfassungsdatum 2022-11-02
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