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Kreitmaier, P. ; Katsoula, G. ; Zeggini, E.

Insights from multi-omics integration in complex disease primary tissues.

Trends Genet. 39, 46-58 (2023)
Verlagsversion DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Genome-wide association studies (GWAS) have provided insights into the genetic basis of complex diseases. In the next step, integrative multi-omics approaches can characterize molecular profiles in relevant primary tissues to reveal the mechanisms that underlie disease development. Here, we highlight recent progress in four examples of complex diseases generated by integrative studies: type 2 diabetes (T2D), osteoarthritis, Alzheimer's disease (AD), and systemic lupus erythematosus (SLE). High-resolution methodologies such as single-cell and spatial omics techniques will become even more important in the future. Furthermore, we emphasize the urgent need to include as yet understudied cell types and increase the diversity of studied populations.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Alzheimer's Disease ; Multi-omics ; Osteoarthritis ; Primary Tissue ; Systemic Lupus Erythematosus ; Type 2 Diabetes; Systemic-lupus-erythematosus; Genome-wide Association; Alzheimers-disease; Osteoarthritis; Susceptibility
Sprache englisch
Veröffentlichungsjahr 2023
Prepublished im Jahr 2022
HGF-Berichtsjahr 2022
ISSN (print) / ISBN 0168-9479
Zeitschrift Trends in Genetics
Quellenangaben Band: 39, Heft: 1, Seiten: 46-58 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)
POF Topic(s) 30205 - Bioengineering and Digital Health
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-506700-001
DOI 10.1016/j.tig.2022.08.005
WOS ID 001011370800001
Scopus ID 85138587479
PubMed ID 36137835
Erfassungsdatum 2022-10-13
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