Knoedler, S. ; Broichhausen, S.* ; Guo, R. ; Dai, R. ; Knoedler, L.* ; Kauke-Navarro, M.* ; Diatta, F.* ; Pomahac, B.* ; Machens, H.G.* ; Jiang, D. ; Rinkevich, Y.
Fibroblasts – the cellular choreographers of wound healing.
Front. Immunol. 14:1233800 (2023)
Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Typ der Hochschulschrift
Herausgeber
Schlagwörter
Fascia ; Fibroblast ; Fibroblast Diversity ; Skin Injury ; Skin Regeneration ; Wound Healing ; Wound Repair; Therapeutic Target; Heterogeneity; Distinct; Differentiation; Regeneration; Papillary; Identification; Subpopulation; Expression; Plasticity
Keywords plus
Sprache
englisch
Veröffentlichungsjahr
2023
Prepublished im Jahr
0
HGF-Berichtsjahr
2023
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
ISBN
Bandtitel
Konferenztitel
Konferzenzdatum
Konferenzort
Konferenzband
Quellenangaben
Band: 14,
Heft: ,
Seiten: ,
Artikelnummer: 1233800
Supplement: ,
Reihe
Verlag
Frontiers
Verlagsort
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Tag d. mündl. Prüfung
0000-00-00
Betreuer
Gutachter
Prüfer
Topic
Hochschule
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Veröffentlichungsdatum
0000-00-00
Anmeldedatum
0000-00-00
Anmelder/Inhaber
weitere Inhaber
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Priorität
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s)
30202 - Environmental Health
Forschungsfeld(er)
Lung Research
PSP-Element(e)
G-509400-001
Förderungen
European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Programme
European Union
German Research Foundation
LEO Foundation
European Research Council
YR is funded by the European Research Council Consolidator Grant (ERC-CoG 819933), the LEO Foundation (LF-OC-21-000835), the German Research Foundation (SFB/TRR359 PILOT), the European Union Horizon 2020 (Marie Curie 955722 SkinTERM), and the European Fou
Copyright
Erfassungsdatum
2023-10-18