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Knoedler, S. ; Broichhausen, S.* ; Guo, R. ; Dai, R. ; Knoedler, L.* ; Kauke-Navarro, M.* ; Diatta, F.* ; Pomahac, B.* ; Machens, H.G.* ; Jiang, D. ; Rinkevich, Y.

Fibroblasts – the cellular choreographers of wound healing.

Front. Immunol. 14:1233800 (2023)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Injuries to our skin trigger a cascade of spatially- and temporally-synchronized healing processes. During such endogenous wound repair, the role of fibroblasts is multifaceted, ranging from the activation and recruitment of innate immune cells through the synthesis and deposition of scar tissue to the conveyor belt-like transport of fascial connective tissue into wounds. A comprehensive understanding of fibroblast diversity and versatility in the healing machinery may help to decipher wound pathologies whilst laying the foundation for novel treatment modalities. In this review, we portray the diversity of fibroblasts and delineate their unique wound healing functions. In addition, we discuss future directions through a clinical-translational lens.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Fascia ; Fibroblast ; Fibroblast Diversity ; Skin Injury ; Skin Regeneration ; Wound Healing ; Wound Repair; Therapeutic Target; Heterogeneity; Distinct; Differentiation; Regeneration; Papillary; Identification; Subpopulation; Expression; Plasticity
Sprache englisch
Veröffentlichungsjahr 2023
HGF-Berichtsjahr 2023
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Quellenangaben Band: 14, Heft: , Seiten: , Artikelnummer: 1233800 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
Förderungen
European Foundation for the Study of Diabetes (EFSD) Anniversary Fund Programme
European Union
German Research Foundation
LEO Foundation
European Research Council
YR is funded by the European Research Council Consolidator Grant (ERC-CoG 819933), the LEO Foundation (LF-OC-21-000835), the German Research Foundation (SFB/TRR359 PILOT), the European Union Horizon 2020 (Marie Curie 955722 SkinTERM), and the European Fou
Scopus ID 85168927208
PubMed ID 37646029
Erfassungsdatum 2023-10-18