PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Zhou, Y.* ; Xu, T.* ; Han, W. ; Wu, Z.* ; Yang, C.* ; Chen, X.*

A review focuses on a neglected and controversial component of SCI: Myelin debris.

Front. Immunol. 15:1436031 (2024)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Myelin sheath, as the multilayer dense structure enclosing axons in humans and other higher organisms, may rupture due to various injury factors after spinal cord injury, thus producing myelin debris. The myelin debris contains a variety of myelin-associated inhibitors (MAIs) and lipid, all inhibiting the repair after spinal cord injury. Through summary and analysis, the present authors found that the inhibition of myelin debris can be mainly divided into two categories: firstly, the direct inhibition mediated by MAIs; secondly, the indirect inhibition mediated by lipid such as cholesterol. It is worth noting that phagocytes are required in the latter indirect inhibition, such as professional phagocytes (macrophages et al.) and non-professional phagocytes (astrocytes et al.). Moreover, complement and the immune system also participate in the phagocytosis of myelin debris, working together with phagocytes to aggravate spinal cord injury. In conclusion, this paper focuses on the direct and indirect effects of myelin debris on spinal cord injury, aiming to provide new inspiration and reflection for the basic research of spinal cord injury and the conception of related treatment.
Impact Factor
Scopus SNIP
Altmetric
5.700
0.000
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter Axon ; Cholesterol ; Foam Cell ; Myelin Debris ; Myelin-associated Inhibitors ; Spinal Cord Injury; Spinal-cord-injury; Receptor Family-member; Nogo Receptor; Axonal Regeneration; Neurite Outgrowth; Cholesterol Accumulation; Inhibitory-activity; Cns Remyelination; Messenger-rna; White-matter
Sprache englisch
Veröffentlichungsjahr 2024
HGF-Berichtsjahr 2024
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Zeitschrift Frontiers in Immunology
Quellenangaben Band: 15, Heft: , Seiten: , Artikelnummer: 1436031 Supplement: ,
Verlag Frontiers
Verlagsort Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Regenerative Biology and Medicine (IRBM)
POF Topic(s) 30202 - Environmental Health
Forschungsfeld(er) Lung Research
PSP-Element(e) G-509400-001
Förderungen Postgraduate Research & Practice Innovation Program of Jiangsu Province
Medical Research Projects of the Health Commission of Jiangsu Province
National Natural Science Foundation of China
DOI 10.3389/fimmu.2024.1436031
WOS ID 001370531000001
Scopus ID 85210994355
PubMed ID 39650659
Erfassungsdatum 2024-12-10
[➜Korrektur melden]