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Rong, Z. ; Ertürk, A. ; Tang, Y.* ; Mai, H.J.*

Tissue clearing and its application in nanoparticle development.

Small:e2410032 (2025)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Nanoparticles are widely used in biomedical applications due to their small size, large surface area, and unique physicochemical properties. These characteristics make them ideal for drug delivery, diagnostic imaging, and therapeutic interventions. Their ability to interact with biological systems at the cellular and molecular levels enables targeted treatments. Understanding the biodistribution of nanoparticles at the cellular level within whole organisms is crucial for assessing their safety and effectiveness; however, proper technologies have been lacking to achieve this. For example, traditional imaging techniques like magnetic resonance imaging (MRI) and computed tomography (CT) often lack the resolution needed, while tissue-section-based methods miss the whole-body systemic view. Recent tissue clearing methods have emerged as a promising solution for 3D visualization of nanoparticles in entire organs, as they enable cellular-level imaging of whole organisms without the need for sectioning. This review explores advancements in diverse tissue clearing techniques and their application in studying nanoparticle biodistribution, providing insights crucial for the development of nanoparticle-based therapies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Schlagwörter 3d Imaging ; Light‐sheet Fluorescence Microscopy ; Nanoparticles ; Tissue Clearing; Light Sheet Microscopy; Single-cell Resolution; Cancer Metastasis; Intact; Visualization; Clarity
ISSN (print) / ISBN 1613-6810
e-ISSN 1613-6829
Zeitschrift Small
Quellenangaben Band: , Heft: , Seiten: , Artikelnummer: e2410032 Supplement: ,
Verlag Wiley
Verlagsort Postfach 101161, 69451 Weinheim, Germany
Begutachtungsstatus Peer reviewed
Institut(e) Institute for Intelligent Biotechnologies (IBIO)
Förderungen Fundamental Research Funds for the Central Universities
NOMIS Human Heart Atlas Project Grant