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Daria, T.* ; Iyer, K.* ; Alkhairo, H.* ; Kho, P.F.* ; Suzuki, K.* ; Hatzikotoulas, K. ; Southam, L. ; Taylor, H.J.* ; Yin, X.* ; Mandla, R.* ; Huerta-Chagoya, A.* ; Rayner, N.W. ; Levin, M.G.* ; Damrauer, S.M.* ; Tsao, P.S.* ; Priest, J.R.* ; Klarin, D.* ; Pirruccello, J.P.* ; Echouffo Tcheugui, J.B.* ; Tcheandjieu, C.*

Mendelian randomization suggests a causal link between glycemic traits and thoracic aortic structures and diseases.

JACC-Basic Transl. Sci. 10:101390 (2025)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We investigate the relationship between glycemic traits-specifically type 2 diabetes mellitus, fasting glucose, fasting insulin, glycated hemoglobin, and 2-hour post-load glucose-and thoracic aortic morphology and diseases. The results indicate an inverse association between elevated glycemic traits and aortic morphology, as well as a reduced risk of thoracic aortic aneurysm. Genetic predictors related to beta-cell proinsulin mechanisms in type 2 diabetes mellitus drive these associations. Key genes such as AGER, GLRX, TCF7L2, and GCK are implicated, highlighting their potential as therapeutic targets for the prevention and treatment of thoracic aortic aneurysm, given their role in glycemic control medication.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Aortic Aneurysm ; Aortic Tissue Expression ; Glycemic Traits ; Mendelian Randomization ; Type 2 Diabetes
ISSN (print) / ISBN 2452-302X
e-ISSN 2452-302X
Zeitschrift JACC: Basic to Translational Science
Quellenangaben Band: 10, Heft: 11, Seiten: , Artikelnummer: 101390 Supplement: ,
Verlag Elsevier
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Translational Genomics (ITG)