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Antò, J.M.* ; Pinart, M.* ; Akdis, M.* ; Auffray, C.* ; Bachert, C.* ; Basagana, X.* ; Carlsen, K.H.* ; Guerra, S.* ; von Hertzen, L.* ; Illi, S.* ; Kauffmann, F.* ; Keil, T.* ; Kiley, J.P.* ; Koppelman, G.H.* ; Lupinek, C.* ; Martinez, F.D.* ; Nawijn, M.C.* ; Postma, D.S.* ; Siroux, V.* ; Smit, H.A.* ; Sterk, P.J.* ; Sunyer, J.* ; Valenta, R.* ; Valverde, S.* ; Akdis, C.A.* ; Annesi-Maesano, I.* ; Ballester, F.* ; Benet, M.* ; Cambon-Thomsen, A.* ; Chatzi, L.* ; Coquet, J.* ; Demoly, P.* ; Gan, W.* ; Garcia-Aymerich, J.* ; Gimeno-Santos, E.* ; Guihenneuc-Jouyaux, C.* ; Haahtela, T.* ; Heinrich, J. ; Herr, M.* ; Hohmann, C.* ; Jacquemin, B.* ; Just, J.* ; Kerkhof, M.* ; Kogevinas, M.* ; Kowalski, M.L.* ; Lambrecht, B.N.* ; Lau, S.* ; Lødrup Carlsen, K.C.* ; Maier, D.* ; Momas, I.* ; Noel, P.* ; Oddie, S.* ; Palkonen, S.* ; Pin, I.* ; Porta, D.* ; Punturieri, A.* ; Ranciere, F.* ; Smith, R.A.* ; Stanic, B.* ; Stein, R.T.* ; van de Veen, W.* ; van Oosterhout, A.J.* ; Varraso, R.* ; Wickman, M.* ; Wijmenga, C.* ; Wright, J.* ; Yaman, G.* ; Zuberbier, T.* ; Bousquet, J.* ; WHO Collaborating Centre on Asthma and Rhinitis (Montpellier)*

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) seminar.

J. Allergy Clin. Immunol. 129, 943-954 (2012)
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Mechanisms of the Development of Allergy (MeDALL), a Seventh Framework Program European Union project, aims to generate novel knowledge on the mechanisms of initiation of allergy. Precise phenotypes of IgE-mediated allergic diseases will be defined in MeDALL. As part of MeDALL, a scientific seminar was held on January 24, 2011, to review current knowledge on the IgE-related phenotypes and to explore how a multidisciplinary effort could result in a new integrative translational approach. This article provides a summary of the meeting. It develops challenges in IgE-related phenotypes and new clinical and epidemiologic approaches to the investigation of allergic phenotypes, including cluster analysis, scale-free models, candidate biomarkers, and IgE microarrays; the particular case of severe asthma was reviewed. Then novel approaches to the IgE-associated phenotypes are reviewed from the individual mechanisms to the systems, including epigenetics, human in vitro immunology, systems biology, and animal models. The last chapter deals with the understanding of the population-based IgE-associated phenotypes in children and adolescents, including age effect in terms of maturation, observed effects of early-life exposures and shift of focus from early life to pregnancy, gene-environment interactions, cohort effects, and time trends in patients with allergic diseases. This review helps to define phenotypes of allergic diseases in MeDALL.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Allergy; Mechanisms of the Development of Allergy; Seventh Framework Program; phenotypes; IgE; asthma; ASTHMA RESEARCH-PROGRAM; OBSTRUCTIVE PULMONARY-DISEASE; WORLD-HEALTH-ORGANIZATION; T-REGULATORY-CELLS; BIRTH-COHORT; CLUSTER-ANALYSIS; RUSSIAN KARELIA; LUNG-FUNCTION; BRONCHIAL HYPERRESPONSIVENESS; DIAGNOSTIC GATEKEEPERS
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 0091-6749
e-ISSN 1097-6825
Zeitschrift The journal of allergy and clinical immunology
Quellenangaben Band: 129, Heft: 4, Seiten: 943-954 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort Amsterdam [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)
POF Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-503900-001
PubMed ID 22386796
DOI 10.1016/j.jaci.2012.01.047
WOS ID 000302144600008
Scopus ID 84862780157
Erfassungsdatum 2012-07-23
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