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möglich sobald bei der ZB eingereicht worden ist.
Emerging role of monoamine oxidase as a therapeutic target for cardiovascular disease.
Curr. Opin. Pharmacol. 33, 64-69 (2017)
In the past decade, accumulating evidence highlighted the role of monoamine oxidases (MAOs) in cardiovascular disease (CVD). MAOs are flavoenzymes located in the outer mitochondrial membrane, responsible for the degradation of neurotransmitters and biogenic amines. During this process they generate hydrogen peroxide, aldehydes and ammonia, species that can target mitochondria and induce mitochondrial dysfunction and cardiomyocyte death. Indeed, MAO inhibition affords cardioprotection in several models of CVD, such as ischemia/reperfusion, heart failure and diabetes. Importantly, a few studies provided encouraging results suggesting that MAO inhibition might be beneficial also in patients with CVD. Thus, selective and reversible MAO inhibitors, currently used as therapy for depression and neurodegenerative disorders, might be considered as candidate drugs for the treatment of CVD.
Impact Factor
Scopus SNIP
Altmetric
5.363
1.482
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Sprache
englisch
Veröffentlichungsjahr
2017
HGF-Berichtsjahr
2017
ISSN (print) / ISBN
1471-4892
e-ISSN
1471-4973
Zeitschrift
Current opinion in pharmacology
Quellenangaben
Band: 33,
Seiten: 64-69
Verlag
Elsevier
Verlagsort
London
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Metabolism and Cell Death (MCD)
POF Topic(s)
30203 - Molecular Targets and Therapies
Forschungsfeld(er)
Genetics and Epidemiology
PSP-Element(e)
G-509900-024
PubMed ID
28528298
Erfassungsdatum
2025-02-27