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Open Access Green as soon as Postprint is submitted to ZB.
Genetics of atopic dermatitis
J. Dtsch. Dermatol. Ges. 9, 670-676 (2011)
Atopic dermatitis (AD) is a multifactorial disease, with a strong genetic predisposition. Genome-wide studies as well as candidate gene studies revealed several susceptibility loci. Since the observation of a strong association of "loss of function" mutations in the filaggrin gene with AD, the epidermal barrier was rediscovered as important pathophysiological co-factor of this disease.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
atopic dermatitis; genetics; filaggrin; epidermal barrier; polymorphisms; SERUM IGE LEVELS; POPULATION-BASED COHORT; OF-FUNCTION MUTATIONS; FILAGGRIN MUTATIONS; PROMOTER POLYMORPHISM; CHILDHOOD ECZEMA; BARRIER FUNCTION; GERMAN PATIENTS; BIRTH COHORT; ASSOCIATION
ISSN (print) / ISBN
1610-0379
e-ISSN
1610-0387
Quellenangaben
Volume: 9,
Issue: 9,
Pages: 670-676
Publisher
Blackwell
Publishing Place
Chichester
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)