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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Neural regulation of cholesterol metabolism.
Curr. Opin. Lipidol. 22, 283-287 (2011)
PURPOSE OF REVIEW: The increasing incidence of obesity and diabetes worldwide are critical risk factors for the development of cardiovascular disease. Although the role of the central nervous system (CNS) in the control of fat mass and glucose metabolism has been studied in detail, less is known about the contribution of neural-derived signals in the development of systemic dyslipidemia. In this review we summarize and analyze evidence suggesting a specific role of the CNS in the control of systemic cholesterol metabolism and circulating plasma lipids levels. RECENT FINDINGS: Although early reports based in lesions or electrical stimulation suggested a role for CNS-derived signals in the development of dyslipidemia, more recent findings have confirmed the involvement of specific neural pathways critical for the neuroendocrine control of cholesterol metabolism and plasma lipid levels. SUMMARY: The identification of the pathways targeted by the CNS to control plasma lipid levels could offer alternative targets to create efficient novel therapies for the treatment of several metabolic syndrome components including dyslipidemia.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0957-9672
e-ISSN
1473-6535
Journal
Current Opinion in Lipidology
Quellenangaben
Volume: 22,
Issue: 4,
Pages: 283-287
Publisher
Lippincott Williams & Wilkins
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)