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Hummel, M.* ; Williams, A.J.* ; Norcross, A.* ; Standl, E.* ; Bonifacio, E.* ; Ziegler, A.-G.* ; Bingley, P.J.*

Proinsulin-specific autoantibodies are relatively infrequent in young offspring with pre-type 1 diabetes.

Diabetes Care 24, 1843-1844 (2001)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Insulin is a β-cell–specific and pivotal autoantigen in type 1 diabetes (1) and is produced after proteolysis of its prohormone proinsulin, which is a potential target of autoimmunity. T-cell studies in the nonobese diabetic (NOD) mouse (2,3) and in prediabetic relatives of patients with type 1 diabetes (4,5) indicate the existence of proinsulin-specific immunodominant epitopes localized in the region between the C-peptide and the A-chain, whereas immune intervention with proinsulin in the NOD mouse can prevent diabetes onset. These studies have led to the proposal of proinsulin as a primary target of autoimmunity associated with type 1 diabetes. At the humoral level, proinsulin-specific autoantibodies have also been reported in humans (6,7). Our own data show, however, that proinsulin autoantibody (PAA) and insulin autoantibody (IAA) levels correlate well in newly diagnosed patients, but IAAs are more sensitive and specific for type 1 diabetes (7). Furthermore, IAA or PAA could be completely displaced with either insulin or …
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 24, Issue: 10, Pages: 1843-1844 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes Research (IDF)
Institute of Pancreatic Islet Research (IPI)