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Schmid, S.* ; Buuck, D.* ; Knopff, A.* ; Bonifacio, E.* ; Ziegler, A.-G.*

BABYDIET, a feasibility study to prevent the appearance of islet autoantibodies in relatives of patients with type 1 diabetes by delaying exposure to gluten.

Diabetologia 47, 1130-1131 (2004)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
To the Editor: The early introduction of foods containing gluten or cereal before the age of 3 months is associated with an increased risk of islet autoimmunity in childhood [1, 2]. A pilot study called BABYDIET is currently underway to determine whether primary intervention through delayed introduction of dietary gluten is feasible and could reduce the incidence of islet autoimmunity in high-risk first degree relatives of patients with Type 1 diabetes. Newborn children are eligible if they are younger than 3 months and are offspring or siblings of patients with Type 1 diabetes and also have HLA genotypes that confer a high diabetes risk (DRB1*03-DQA1*0501-DQB1*0201/DRB1*04-DQA1*0301-DQB1*0302; DRB1*04-DQA1*0301-DQB1*0302/DRB1*04-DQA1*0301-DQB1*0302 or DRB1*03-DQA1*0501-DQB1*0201/ DRB1*03-DQA1*0501-DQB1*0201). The parents of all children are informed of the potential benefits of gluten avoidance in animal models of autoimmune diabetes and of the increased risk of islet autoimmunity found  
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Publication type Article: Journal article
Document type Scientific Article
Keywords Risk
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Journal Diabetologia
Quellenangaben Volume: 47, Issue: 6, Pages: 1130-1131 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes Research (IDF)
Institute of Pancreatic Islet Research (IPI)