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Hummel, S.* ; Pflüger, M.* ; Kreichauf, S.* ; Hummel, M.* ; Ziegler, A.-G.*

Predictors of overweight during childhood in offspring of parents with type 1 diabetes.

Diabetes Care 32, 921-925 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
OBJECTIVE- To study which perinatal factors affect the risk of childhood overweight in offspring with a first-degree relative (FDR) with type I diabetes and to determine whether maternal diabetes is an independent contributor to overweight risk. RESEARCH DESIGN AND METHODS- Data on a child's weight and height were collected at age 2, 5, and 8 years from 1,214 children participating in the prospective BABYDIAB study. All children had an FDR With type 1. diabetes, including 783 whose mothers had type I diabetes. Overweight was defined as BMI percentile >= 90. Data on birth size, breast-feeding, Maternal age, and smoking during pregnancy were collected by questionnaires. Risk estimates were calculated by logistic regression analyses. RESULTS- Breastfeeding duration and birth size both contributed significantly to overweight risk at all age intervals. Full breast-feeding >4 months or any breast-feeding >6 months reduced risk of overweight (aged 8 years: odds ratio 0.3 [95% CI 0.2-0.7], P = 0.004; and 0.3 [01-0.6], P = 0.001). Large-for-gestational-age status increased risk of overweight (aged 8 years: 2.4 [1.4-4.3], P = 0.002). Importantly, no evidence was found for an independent contribution of maternal type 1 diabetes to childhood overweight. CONCLUSIONS- Our findings indicate that maternal type 1 diabetes is not an independent risk factor for overweight during childhood in offspring of type 1 diabetic mothers but that factors associated with maternal type 1 diabetes, such as short breast-feeding duration and high birth size, predispose children to overweight during childhood.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Body-mass Index; Birth-weight; Obesity; Risk; Infants; Mothers; Women; Life; Children; German
ISSN (print) / ISBN 0149-5992
e-ISSN 1935-5548
Journal Diabetes Care
Quellenangaben Volume: 32, Issue: 5, Pages: 921-925 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, Va.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)