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Open Access Green as soon as Postprint is submitted to ZB.
The dual role of the urokinase receptor system in pericellular proteolysis and cell adhesion: Implications for cardiovascular function.
Basic Res. Cardiol. 94, 315-321 (1999)
Cell-cell and cell-matrix interactions are key events in morphogenetic processes during development and tissue remodelling. In the vascular system, overexpression of adhesion receptors such as integrins, protease (receptors) or dysregulation of adhesive interactions are directly related to the pathophysiology of cardiovascular diseases (atherosclerosis, restenosis, thrombosis) or angiogenesis-driven tumor progression. Protease cascades such as the plasminogen activation system exhibit a dual role in cell invasion by promoting pericellular proteolysis as well as by regulating cell adhesion and migration in a non-proteolytic fashion. In both these mechanisms, the urokinase receptor (uPAR) plays a central role and may become engaged in complexes with beta1-, beta2-, and beta3-integrins. This article will focus on the molecular and functional interactions between the uPAR system and vascular integrins and discuss implications for cardiovascular function.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0300-8428
e-ISSN
1435-1803
Journal
Basic Research in Cardiology
Quellenangaben
Volume: 94,
Issue: 5,
Pages: 315-321
Publisher
Springer
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)