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Open Access Green as soon as Postprint is submitted to ZB.
Mineralocorticoid-stimulating activity of adipose tissue.
Best Pract. Res. Clin. Endocrinol. Metab. 19, 567-575 (2005)
Obesity is strongly associated with arterial hypertension. A positive correlation between obesity and plasma aldosterone levels has been observed by different investigators, suggesting that an abnormal secretion of aldosterone in obesity contributes to the development of arterial hypertension in obese subjects. The mechanisms proposed to explain this abnormal aldosterone production mainly involve the adipose renin-angiotensin system, an indirect effect of increased fatty acids, and direct adrenal stimulation by adipocyte secretory products. Indeed, adipose mineralocorticoid-stimulating activity was recently observed in isolated human adipocytes, suggesting a hitherto unknown direct involvement of adipose tissue in the regulation of blood pressure in obesity.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1521-690X
e-ISSN
1532-1908
Quellenangaben
Volume: 19,
Issue: 4,
Pages: 567-575
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)