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Successful doxycycline treatment of lymphatic fistulas: Report of five cases and review of the literature.
Langenbecks Arch. Surg. 391, 435-438 (2006)
BACKGROUND AND AIMS: Lymphatic fistulas are commonly known complications after lymph node or soft tissue resection, requiring long and sometimes difficult therapy. Doxycycline is an antibiotic agent, which was used in the treatment of pneumothoraces and pleural effusions. The aim of the study was to evaluate the effect of local doxycycline instillation on postoperative lymphatic effusions. MATERIALS AND METHODS: Five patients with postoperative lymphatic fistulas of different locations (inguinal, gluteal, and thoracic) were included. Patients received local doxycycline instillation after a postoperative observation period of 19-27 days without spontaneous closure of the fistulas. RESULTS: Postoperative lymphatic fistulas closed after a single injection of doxycycline in four out of five patients within 2 days, in one patient, injection had to be repeated to achieve closure of the fistula. Drain removal was possible within 4 days after instillation in all patients; no complications occurred. CONCLUSIONS: Doxycycline can be used for treatment of persistent postoperative lymphatic fistulas in different locations. In further studies, this therapeutic concept should be evaluated with larger numbers of patients with regard to the ideal point of time, frequency, and mode of application.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
1435-2443
e-ISSN
1435-2451
Journal
Langenbeck's Archives of Surgery
Quellenangaben
Volume: 391,
Issue: 4,
Pages: 435-438
Publisher
Springer
Publishing Place
Berlin ; Heidelberg [u.a.]
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)