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Biemann, R.* ; Blüher, M. ; Isermann, B.*

Exposure to endocrine-disrupting compounds such as phthalates and bisphenol A is associated with an increased risk for obesity.

Best Pract. Res. Clin. Endocrinol. Metab. 35:101546 (2021)
Postprint DOI PMC
Open Access Green
Increasing evidence from epidemiological, animal and in vitro studies suggests that the increased production of synthetic chemicals that interfere with the proper functioning of the hormonal system, so-called endocrine-disrupting compounds (EDCs), might be involved in the development and rapid spread of obesity, coined the obesity epidemic. Recent findings have demonstrated that EDCs may interfere with hormonal receptors that regulate adipogenesis and metabolic pathways. Furthermore, prenatal exposure to EDCs has been shown to influence the metabolism of the developing embryo through epigenetic mechanisms and to promote obesity in subsequent generations. In this Review, we discuss the potential impact of bisphenol A (BPA) and phthalate-based plasticizers on obesity and obesity-related metabolic disorders. Special emphasis is given to the obesogenic effects of prenatal exposure and strategies for identifying, regulating, and replacing EDCs.
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Publication type Article: Journal article
Document type Review
Keywords Bisphenol A ; Endocrine-disrupting Compounds ; Obesity ; Phthalates; Estrogen-receptor-alpha; Body-mass Index; Dna Methylation; Adipogenic Differentiation; Di(2-ethylhexyl) Phthalate; Adipocyte Differentiation; Waist Circumference; Human Health; Stem-cells; Chemicals
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1521-690X
e-ISSN 1532-1908
Journal Best Practice and Research Clinical Endocrinology and Metabolism
Quellenangaben Volume: 35, Issue: 5, Pages: , Article Number: 101546 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506501-001
Grants "Stiftung Pathobiochemie und Molekulare Diagnostik" (SPMD)
DOI 10.1016/j.beem.2021.101546
WOS ID WOS:000705235700012
Scopus ID 85107051483
PubMed ID 33966978
Erfassungsdatum 2021-06-23
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