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Grahammer, F.* ; Huber, T.B.* ; Artunc, F.

Role of mTor signaling for tubular function and disease.

Physiology 36, 350-358 (2021)
Verlagsversion DOI PMC
Free by publisher
The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities i.e. diabetic nephropathy, AKI or hyperkalemia.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Enac ; Romk ; Endocytosis ; Mtor ; Proximal Tubule; Mammalian Target; Binding Partner; Na+ Channel; Life-span; Rapamycin; Kidney; Activation; Complex; Sgk1; Kinase
ISSN (print) / ISBN 1548-9213
e-ISSN 1548-9221
Zeitschrift Physiology
Quellenangaben Band: 36, Heft: 6, Seiten: 350-358 Artikelnummer: , Supplement: ,
Verlag American Physiological Society
Verlagsort 6120 Executive Blvd, Suite 600, Rockville, Md, United States
Nichtpatentliteratur Publikationen
Institut(e) Institute of Diabetes Research and Metabolic Diseases (IDM)
Förderungen Bundesministerium fur Bildung und Forschung (BMBF)
Else Kröner-Fresenius-Stiftung (EKFS)
EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
Deutsche Forschungsgemeinschaft (DFG)